Natural coumarins as potential anti-SARS-CoV-2 agents supported by docking analysis

被引：37

作者：

Abdelmohsen, Usama Ramadan ^{[1
,2
]}

Albohy, Amgad ^{[3
]}

Abdulrazik, Basma S. ^{[3
]}

Bayoumi, Soad A. L. ^{[4
]}

Malak, Lourin G. ^{[4
]}

Khallaf, Iman S. A. ^{[4
]}

Bringmann, Gerhard ^{[5
]}

Farag, Salwa F. ^{[4
,6
]}

机构：

[1] Deraya Univ, Fac Pharm, Dept Pharmacognosy, 7 Univ Zone, New Minia City 61111, Egypt

[2] Minia Univ, Fac Pharm, Dept Pharmacognosy, Al Minya 61519, Egypt

[3] British Univ Egypt BUE, Dept Pharmaceut Chem, Fac Pharm, Suez Desert Rd, Cairo 11837, Egypt

[4] Assiut Univ, Fac Pharm, Pharmacognosy Dept, Assiut 71526, Egypt

[5] Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany

[6] Taif Univ, Coll Pharm, Pharmacognosy Dept, At Taif, Saudi Arabia

来源：

RSC ADVANCES | 2021年 / 11卷 / 28期

关键词：

REVERSE-TRANSCRIPTASE; SARS-COV-2; CORONAVIRUS; INHIBITORS; COVID-19; TOOL;

D O I：

10.1039/d1ra01989a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

COVID-19 is a global pandemic first identified in China, causing severe acute respiratory syndrome. One of the therapeutic strategies for combating viral infections is the search for viral spike proteins as attachment inhibitors among natural compounds using molecular docking. This review aims at shedding light on the antiviral potential of natural products belonging to the natural-products class of coumarins up to 2020. Moreover, all these compounds were filtered based on ADME analysis to determine their physicochemical properties, and the best 74 compounds were selected. Using virtual-screening methods, the selected compounds were investigated for potential inhibition of viral main protease (Mpro), viral methyltransferase (nsp16/10 complex), viral recognition binding domain (RBD) of S-protein, and human angiotensin-converting enzyme 2 (ACE2), which is the human receptor for viral S-protein targets, using molecular-docking studies. Promising potential results against SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) and methyltransferase (nsp16) are presented.

引用

页码：16970 / 16979

页数：10

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