Ezetimibe and recent clinical trials: a look on the bright side

被引：4

作者：

Ahmed, Mohamed H. ^{[1
]}

机构：

[1] Southampton Univ Hosp NHS Trust, Dept Chem Pathol, Southampton SO16 6YD, Hants, England

来源：

EXPERT OPINION ON DRUG SAFETY | 2010年 / 9卷 / 04期

关键词：

clinical trials; ezetimibe; hyperlipidemia; non-alcoholic fatty liver disease; FATTY LIVER-DISEASE; DENSITY-LIPOPROTEIN CHOLESTEROL; TYPE-2; DIABETIC-PATIENTS; INTIMA-MEDIA THICKNESS; CARDIOVASCULAR-DISEASE; SIMVASTATIN;

D O I：

10.1517/14740331003702376

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Ezetimibe is a lipid lowering medication that is able to inhibit dietary cholesterol. It can be used alone or in combination with statin therapy. The definitive IMPROVE-IT (Improved Reduction of Outcomes: Vytorin Efficacy International Trial) study will reveal the impact of ezetimibe in decreasing coronary vascular disease. The SHARP trial (Study of Heart And Renal Protection) will evaluate the effects of lowering low-density lipoprotein cholesterol with ezetimibe 10 mg and simvastatin 20 mg/day versus placebo in patients with chronic kidney disease. Recently, in a post-marketing analysis of reported adverse events, it was clearly demonstrated that ezetimibe or the combination of ezetimibe and simvastatin does not increase risk of cancer. The current evidence suggests that ezetimibe should be considered as a safe and effective lipid-lowering agent. This article projects the potential benefits of current and possible future ezetimibe clinical trials.

引用

页码：511 / 514

页数：4

共 19 条

[1] Ezetimibe, and the combination of ezetimibe/simvastatin, and risk of cancer: A post-marketing analysis [J].

Alsheikh-Ali, Alawi A. ;

Karas, Richard H. .

JOURNAL OF CLINICAL LIPIDOLOGY, 2009, 3 (02) :138-142

[2] Association between change in high density lipoprotein cholesterol and cardiovascular disease morbidity and mortality: systematic review and meta-regression analysis [J].

Briel, Matthias ;

Ferreira-Gonzalez, Ignacio ;

You, John J. ;

Karanicolas, Paul J. ;

Akl, Elie A. ;

Wu, Ping ;

Blechacz, Boris ;

Bassler, Dirk ;

Wei, Xinge ;

Sharman, Asheer ;

Whitt, Irene ;

da Silva, Suzana Alves ;

Khalid, Zahira ;

Nordmann, Alain J. ;

Zhou, Qi ;

Walter, Stephen D. ;

Vale, Noah ;

Bhatnagar, Neera ;

O'Regan, Christopher ;

Mills, Edward J. ;

Bucher, Heiner C. ;

Montori, Victor M. ;

Guyatt, Gordon H. .

BMJ-BRITISH MEDICAL JOURNAL, 2009, 338

[3] A retrospective analysis of ezetimibe treatment in renal transplant recipients [J].

Buchanan, C ;

Smith, L ;

Corbett, J ;

Nelson, E ;

Shihab, F .

AMERICAN JOURNAL OF TRANSPLANTATION, 2006, 6 (04) :770-774

[4] Ezetimibe improves liver steatosis and insulin resistance in obese rat model of metabolic syndrome [J].

Deushi, Michiyo ;

Nomura, Mitsunori ;

Kawakami, Akio ;

Haraguchi, Mihoko ;

Ito, Mizuho ;

Okazaki, Mitsuyo ;

Ishii, Hideto ;

Yoshida, Masayuki .

FEBS LETTERS, 2007, 581 (29) :5664-5670

[5] Effect of Statins Alone Versus Statins Plus Ezetimibe on Carotid Atherosclerosis in Type 2 Diabetes [J].

Fleg, Jerome L. ;

Mete, Mihriye ;

Howard, Barabara V. ;

Umans, Jason G. ;

Roman, Mary J. ;

Ratner, Robert E. ;

Silverman, Angela ;

Galloway, James M. ;

Henderson, Jeffrey A. ;

Weir, Matthew R. ;

Wilson, Charlton ;

Stylianou, Mario ;

Howard, Wm. James .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2008, 52 (25) :2198-2205

[6] HIGH-DENSITY LIPOPROTEIN CHOLESTEROL AND CARDIOVASCULAR-DISEASE - 4 PROSPECTIVE AMERICAN-STUDIES [J].

GORDON, DJ ;

PROBSTFIELD, JL ;

GARRISON, RJ ;

NEATON, JD ;

CASTELLI, WP ;

KNOKE, JD ;

JACOBS, DR ;

BANGDIWALA, S ;

TYROLER, HA .

CIRCULATION, 1989, 79 (01) :8-15

[7]

Grundy Scott M, 2004, J Am Coll Cardiol, V44, P720, DOI 10.1016/j.jacc.2004.07.001

[8] Simvastatin with or without ezetimibe in familial hypercholesterolemia [J].

Kastelein, John J. P. ;

Akdim, Fatima ;

Stroes, Erik S. G. ;

Zwinderman, Aeilko H. ;

Bots, Michiel L. ;

Stalenhoef, Anton F. H. ;

Visseren, Frank L. J. ;

Sijbrands, Eric J. G. ;

Trip, Mieke D. ;

Stein, Evan A. ;

Gaudet, Daniel ;

Duivenvoorden, Raphael ;

Veltri, Enrico P. ;

Marais, A. David ;

de Groot, Eric .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (14) :1431-1443

[9] The Second United Kingdom Heart and Renal Protection (UK-HARP-II) Study: A randomized controlled study of the biochemical safety and efficacy of adding ezetimibe to simvastatin as initial therapy among patients with CKD [J].

Landray, M ;

Baigent, C ;

Leaper, C ;

Adu, D ;

Altmann, P ;

Armitage, J ;

Ball, S ;

Baxter, A ;

Blackwell, L ;

Cairns, HS ;

Carr, S ;

Collins, R ;

Kourellias, K ;

Rogerson, M ;

Scoble, JE ;

Tomson, CRV ;

Warwick, G ;

Wheeler, DC .

AMERICAN JOURNAL OF KIDNEY DISEASES, 2006, 47 (03) :385-395

[10] Ezetimibe ameliorates cholecystosteatosis [J].

Mathur, Abhishek ;

Walker, Julia J. ;

Al-Azzawi, Hayder H. ;

Lu, Debao ;

Swartz-Basile, Deborah. A. ;

Nakeeb, Attila ;

Pitt, Henry A. .

SURGERY, 2007, 142 (02) :228-233

← 1 2 →