Hepcidin in the diagnosis of iron disorders

被引：325

作者：

Girelli, Domenico ^{[1
]}

Nemeth, Elizabeta ^{[2
]}

Swinkels, Dorine W. ^{[3
]}

机构：

[1] Univ Verona, Veneto Reg Referral Ctr Iron Metab Disorders, Azienda Osped Univ Integrata Verona, Sect Internal Med,Dept Med, I-37100 Verona, Italy

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA

[3] Radboud Univ Nijmegen, Med Ctr, Translat Metab Lab, Dept Lab Med, NL-6525 ED Nijmegen, Netherlands

来源：

BLOOD | 2016年 / 127卷 / 23期

关键词：

SERUM HEPCIDIN; BETA-THALASSEMIA; YOUNG-CHILDREN; TIME-COURSE; DEFICIENCY; HORMONE; ERYTHROPOIESIS; METABOLISM; DISEASE; ANEMIA;

D O I：

10.1182/blood-2015-12-639112

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The discovery of the iron-regulatory hormone hepcidin in 2001 has revolutionized our understanding of iron disorders, and its measurement should advance diagnosis/treatment of these conditions. Although several assays have been developed, a gold standard is still lacking, and efforts toward harmonization are ongoing. Nevertheless, promising applications can already be glimpsed, ranging from the use of hepcidin levels for diagnosing iron-refractory iron deficiency anemia to global health applications such as guiding safe iron supplementation in developing countries with high infection burden.

引用

页码：2809 / 2813

页数：5

共 80 条

[1] Testosterone Suppresses Hepcidin in Men: A Potential Mechanism for Testosterone-Induced Erythrocytosis [J].

Bachman, Eric ;

Feng, Rui ;

Travison, Thomas ;

Li, Michelle ;

Olbina, Gordana ;

Ostland, Vaughn ;

Ulloor, Jagadish ;

Zhang, Anqi ;

Basaria, Shehzad ;

Ganz, Tomas ;

Westerman, Mark ;

Bhasin, Shalender .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2010, 95 (10) :4743-4747

[2] Serum Hepcidin in Inflammatory Bowel Diseases: Biological and Clinical Significance [J].

Bergamaschi, Gaetano ;

Di Sabatino, Antonio ;

Albertini, Riccardo ;

Costanzo, Filippo ;

Guerci, Marco ;

Masotti, Michela ;

Pasini, Alessandra ;

Massari, Alessandro ;

Campostrini, Natascia ;

Corbella, Michela ;

Girelli, Domenico ;

Corazza, Gino Roberto .

INFLAMMATORY BOWEL DISEASES, 2013, 19 (10) :2166-2172

[3] Hepcidin levels predict nonresponsiveness to oral iron therapy in patients with iron deficiency anemia [J].

Bregman, David B. ;

Morris, David ;

Koch, Todd A. ;

He, Andy ;

Goodnough, Lawrence T. .

AMERICAN JOURNAL OF HEMATOLOGY, 2013, 88 (02) :97-101

[4] Iron Deficiency: What Are the Future Trends in Diagnostics and Therapeutics? [J].

Brugnara, Carlo ;

Adamson, John ;

Auerbach, Michael ;

Kane, Robert ;

Macdougall, Iain ;

Mast, Alan .

CLINICAL CHEMISTRY, 2013, 59 (05) :740-745

[5] Iron deficiency in the elderly population, revisited in the hepcidin era [J].

Busti, Fabiana ;

Campostrini, Natascia ;

Martinelli, Nicola ;

Girelli, Domenico .

FRONTIERS IN PHARMACOLOGY, 2014, 5

[6] Treating Iron Overload [J].

Camaschella, Clara .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 368 (24) :2325-2327

[7] Serum levels of the hepcidin-20 isoform in a large general population: The Val Borbera study [J].

Campostrini, Natascia ;

Traglia, Michela ;

Martinelli, Nicola ;

Corbella, Michela ;

Cocca, Massimiliano ;

Manna, Daniele ;

Castagna, Annalisa ;

Masciullo, Corrado ;

Silvestri, Laura ;

Olivieri, Oliviero ;

Toniolo, Daniela ;

Camaschella, Clara ;

Girelli, Domenico .

JOURNAL OF PROTEOMICS, 2012, 76 :28-35

[8] Host iron status and iron supplementation mediate susceptibility to erythrocytic stage Plasmodium falciparum [J].

Clark, Martha A. ;

Goheen, Morgan M. ;

Fulford, Anthony ;

Prentice, Andrew M. ;

Elnagheeb, Marwa A. ;

Patel, Jaymin ;

Fisher, Nancy ;

Taylor, Steve M. ;

Kasthuri, Raj S. ;

Cerami, Carla .

NATURE COMMUNICATIONS, 2014, 5

[9] Functional and Clinical Impact of Novel Tmprss6 Variants in Iron-Refractory Iron-Deficiency Anemia Patients and Genotype-Phenotype Studies [J].

De Falco, Luigia ;

Silvestri, Laura ;

Kannengiesser, Caroline ;

Moran, Erica ;

Oudin, Claire ;

Rausa, Marco ;

Bruno, Mariasole ;

Aranda, Jessica ;

Argiles, Bienvenida ;

Yenicesu, Idil ;

Falcon-Rodriguez, Maria ;

Yilmaz-Keskin, Ebru ;

Kocak, Ulker ;

Beaumont, Carole ;

Camaschella, Clara ;

Iolascon, Achille ;

Grandchamp, Bernard ;

Sanchez, Mayka .

HUMAN MUTATION, 2014, 35 (11) :1321-1329

[10] Practice guidelines for the diagnosis and management of microcytic anemias due to genetic disorders of iron metabolism or heme synthesis [J].

Donker, Albertine E. ;

Raymakers, Reinier A. P. ;

Vlasveld, L. Thom ;

van Barneveld, Teus ;

Terink, Rieneke ;

Dors, Natasja ;

Brons, Paul P. T. ;

Knoers, Nine V. A. M. ;

Swinkels, Dorine W. .

BLOOD, 2014, 123 (25) :3873-3886

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