Molecular mechanisms of action of hesperidin in cancer: Recent trends and advancements

被引：167

作者：

Aggarwal, Vaishali ^{[1
]}

Tuli, Hardeep S. ^{[2
]}

Thakral, Falak ^{[2
]}

Singhal, Paavan ^{[2
]}

Aggarwal, Diwakar ^{[2
]}

Srivastava, Saumya ^{[3
]}

Pandey, Anjana ^{[3
]}

Sak, Katrin ^{[4
]}

Varol, Mehmet ^{[5
]}

Khan, Md. Asaduzzaman ^{[6
]}

Sethi, Gautam ^{[7
]}

机构：

[1] PGIMER, Dept Histopathol, Chandigarh 160012, India

[2] Maharishi Markandeshwar Deemed Be Univ, Dept Biotechnol, Ambala 133207, India

[3] MNNIT Allahabad, Dept Biotechnol, Prayagraj 211004, India

[4] Praeventio, EE-50407 Tartu, Estonia

[5] Mugla Sitki Kocman Univ, Fac Sci, Dept Mol Biol & Genet, TR-48000 Mugla, Turkey

[6] Southwest Med Univ, Res Ctr Preclin Med, Luzhou 646000, Peoples R China

[7] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Pharmacol, Singapore 117600, Singapore

来源：

EXPERIMENTAL BIOLOGY AND MEDICINE | 2020年 / 245卷 / 05期

关键词：

Hesperidin; anticancer; synergistic effect; nanotechnology; HUMAN HEPATOCELLULAR-CARCINOMA; NF-KAPPA-B; CITRUS FLAVONOIDS HESPERIDIN; HESPERETIN INDUCES APOPTOSIS; NECROSIS-FACTOR-ALPHA; OXIDATIVE STRESS; ANTIOXIDANT ACTIVITY; LUNG CARCINOGENESIS; NATURAL-PRODUCTS; PPAR-GAMMA;

D O I：

10.1177/1535370220903671

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Hesperidin belongs to flavanones class of flavonoids and is known to possess broad-spectrum applicability to prevent dreadful diseases such as cardiovascular disease, neurodegeneration, and cancer. The reported anticancer effects of hesperidin have been found to be associated with its anti-oxidant and anti-inflammatory activities. Hesperidin interacts with numerous recognized cellular targets and inhibits cancer cell proliferation by inducing apoptosis and cell cycle arrest. In addition, evidence has suggested its promising role in inhibiting tumor cell metastasis, angiogenesis, and chemoresistance. The present mini-review highlights the ongoing development to identify hesperidin targets in cancer. Furthermore, the potential of nano technology-based hesperidin combinations and delivery systems will also be discussed. Overall, this review highlights all the possible molecular targets affected by hesperidin in tumor cells on a single platform. Impact statement Experimental findings from numerous studies have demonstrated the anticancer effects of hesperidin (Hesp) to be associated with anti-oxidant and anti-inflammatory activities along with its potential role in inhibiting the tumor cell metastasis and angiogenesis. Additionally, Hesp can also reverse drug resistance of cancer cells, which make it a promising candidate to be used in combination with existing anti-cancer drugs. This review will be helpful for upcoming researchers and scientific community to find out complete capsular package about cancer drug targets of Hesp and its role in modulating various important hallmarks of cancer.

引用

页码：486 / 497

页数：12

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