Differences in clinical manifestations among Cryptosporidium species and subtypes in HIV-infected persons

被引：170

作者：

Cama, Vitaliano A.

Ross, Jennifer M.

Crawford, Sara

Kawai, Vivian

Chavez-Valdez, Raul

Vargas, Daniel

Vivar, Aldo

Ticona, Eduardo

Navincopa, Marco

Williamson, John

Ortega, Ynes

Gilman, Robert H.

Bern, Caryn

Xiao, Lihua

机构：

[1] Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Atlanta, GA 30341 USA

[2] Johns Hopkins Univ, Baltimore, MD USA

[3] Univ Georgia, Griffin, GA USA

[4] Hosp Mayo, Lima, Peru

[5] Hosp Arzobispo Loayza, Lima, Peru

[6] Asociac Benefica PRISMA, Lima, Peru

来源：

JOURNAL OF INFECTIOUS DISEASES | 2007年 / 196卷 / 05期

关键词：

D O I：

10.1086/519842

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We performed a cross-sectional study to determine the epidemiology of Cryptosporidium in human immunodeficiency virus (HIV)-infected persons at 3 diagnostic levels: microscopy, genotypes of Cryptosporidium, and subtype families of C. hominis and C. parvum. The study enrolled 2490 HIV-infected persons in Lima, Peru, and 230 were microscopy positive for Cryptosporidium infection. Specimens from 193 participants were available for genotyping. They had C. hominis (141 persons), C. parvum (22 persons), C. meleagridis (17 persons), C. canis (6 persons), C. felis (6 persons), and C. suis (1 person) infection. Although microscopy results showed that Cryptosporidium infections were associated with diarrhea, only infections with C. canis, C. felis, and subtype family Id of C. hominis were associated with diarrhea, and infection with C. parvum was associated with chronic diarrhea and vomiting. These results demonstrate that different Cryptosporidium genotypes and subtype families are linked to different clinical manifestations.

引用

页码：684 / 691

页数：8

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