Novel synthesis of a 2H-1,2-benzothiazine-1,1-dioxide derivative

被引：5
作者：
Bassin, JP [1 ]
Frearson, MJ
Al-Nawwar, K
机构：
[1] Amer Univ Beirut, Dept Chem, Beirut, Lebanon
[2] Univ Hertfordshire, Dept Phys Sci, Hatfield AL10 9AB, Herts, England
来源：
SYNTHETIC COMMUNICATIONS | 2000年 / 30卷 / 20期
关键词：
Basic conditions - Benzoyl group - Cyclohexyl;
D O I：
10.1080/00397910008086996
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We report a novel synthesis of 4-chloro-2-cyclohexyl-6,7-dimethoxy-2H-1,2-benzothiazine-l,l-dioxide 6 from 3,4-dimethoxychalcone 1. Chlorosulfonation of 1 followed by amination, then epoxidation under basic conditions with immediate elimination of the benzoyl group and electrophilic chlorination resulted in 6. A mechanism is suggested.
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收藏
页码：3693 / 3701
页数：9
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