Nanoparticles for multiplex diagnostics and imaging

被引:77
作者
Wang, Lin
O'Donoghue, Meghan B.
Tan, Weihong [1 ]
机构
[1] Univ Florida, Ctr Res BioNano Interface, Dept Chem, Shands Canc Ctr, Gainesville, FL 32611 USA
[2] UF Genet Inst, Gainesville, FL 32611 USA
关键词
bioassay; encoded beads; FRET silica nanoparticles; multiplex analysis; nanoscience; nanotechnology; optical encoding; quantum dots;
D O I
10.2217/17435889.1.4.413
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The drive to understand biology and medicine at the molecular level with accurate quantitation demands much of current high-throughput analysis systems. Nanomaterials and nanotechnology combined with modern instrumentation have the potential to address this emerging challenge. Using a variety of nanomaterials for multiplex diagnostics and imaging applications will offer sensitive, rapid and cost-effective solutions for the modern clinical laboratory. New nanomaterials have been developed with optical-encoding capabilities for selective tagging of a wide range of medically important targets, including bacteria, cancer cells and individual molecules, such as proteins and DNA, in a single assay. We envision further development in this field will provide numerous advanced tools with increased sensitivity and improved multiplexing capability, for unique applications in molecular biology, genomics and drug discovery.
引用
收藏
页码:413 / 426
页数:14
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