Synthesis, DFT, and eco-friendly insecticidal activity of some N-heterocycles derived from 4-((2-oxo-1,2-dihydroquinolin-3-yl) methylene)-2-phenyloxazol-5(4H)-one

被引：36
作者：
Ghareeb, Eman A. [1 ]
Mahmoud, Naglaa F. H. [1 ]
El-Bordany, Eman A. [1 ]
El-Helw, Eman A. E. [1 ]
机构：
[1] Ain Shams Univ, Fac Sci, Chem Dept, Cairo 11566, Egypt
来源：
BIOORGANIC CHEMISTRY | 2021年 / 112卷
关键词：
Insecticidal; Oxazolone; Quinolone; Benzimidazole; Triazinone; IN-VITRO ANTIBACTERIAL; DERIVATIVES; HYBRIDS; DESIGN;
D O I：
10.1016/j.bioorg.2021.104945
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A new series of nitrogen heterocycles encompassing a quinoline scaffold such as imidazolone, benzimidazole, triazinone, triazole, and thiazole derivatives was synthesized utilizing the readily obtainable building block synthon, 4-((2-oxo-1,2-dihydroquinolin-3-yl)methylene)-2-phenyloxazol-5(4H)-one (3). It was interesting that the fused heterocycle, pyranoquinoline derivative 15 was successfully synthesized by different routes of reactions. The synthesized compounds were evaluated for their insecticidal activity and compounds 6, 17, and 20 were the most potent against both Mythimna separata and Nilaparvata lugens. The DFT study was performed for the most potent compounds.
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页数：16
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