Nociceptive brain activity as a measure of analgesic efficacy in infants

被引：76

作者：

Hartley, Caroline ^{[1
]}

Duff, Eugene P. ^{[2
]}

Green, Gabrielle ^{[1
]}

Mellado, Gabriela Schmidt ^{[1
]}

Worley, Alan ^{[3
]}

Rogers, Richard ^{[4
]}

Slater, Rebeccah ^{[1
]}

机构：

[1] Univ Oxford, Dept Paediat, Oxford OX3 9DU, England

[2] Univ Oxford, Nuffield Dept Clin Neurosci, Funct Magnet Resonance Imaging Brain Ctr, Oxford OX3 9DU, England

[3] Great Ormond St Hosp Sick Children, Dept Clin Neurophysiol, London WC1N 3JH, England

[4] John Radcliffe Hosp, Nuffield Dept Anaesthesia, Oxford OX3 9DU, England

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2017年 / 9卷 / 388期

基金：

英国惠康基金;

关键词：

TOPICAL AMETHOCAINE GEL; BLIND CONTROLLED-TRIAL; NEWBORN-INFANTS; PROCEDURAL PAIN; INITIAL-VALIDATION; RANDOMIZED-TRIAL; HEEL PRICK; TETRACAINE; ANESTHESIA; PLACEBO;

D O I：

10.1126/scitranslmed.aah6122

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Pain in infants is undertreated and poorly understood, representing a major clinical problem. In part, this is due to our inability to objectively measure pain in nonverbal populations. We present and validate an electroencephalography-based measure of infant nociceptive brain activity that is evoked by acute noxious stimulation and is sensitive to analgesic modulation. This measure should be valuable both for mechanistic investigations and for testing analgesic efficacy in the infant population.

引用

页数：10

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