Drug Abuse Relapse Rates Linked to Level of Education: Can We Repair Hypodopaminergic-Induced Cognitive Decline With Nutrient Therapy?

被引:8
作者
Blum, Kenneth [1 ,2 ,3 ,4 ,5 ,6 ,7 ,8 ,9 ]
Schoenthaler, Stephen J. [3 ,10 ,11 ]
Oscar-Berman, Marlene [12 ,13 ,14 ]
Giordano, John [3 ]
Madigan, Margaret A. [6 ,8 ,9 ]
Braverman, Eric R. [2 ,6 ]
Han, David [1 ,15 ]
机构
[1] Univ Florida, Coll Med, Dept Psychiat, Gainesville, FL 32611 USA
[2] Univ Florida, Coll Med, McKnight Brain Inst, Gainesville, FL 32611 USA
[3] Natl Inst Holist Addict Studies, Dept Clin Res, North Miami Beach, FL USA
[4] Univ Vermont, Ctr Clin & Translat Sci, Human Integrated Serv Unit, Dept Psychiat, Burlington, VT USA
[5] Univ Vermont, Coll Med, Burlington, VT USA
[6] PATH Fdn, Dept Clin Neurol, New York, NY USA
[7] IGene Inc, Dept Nutrigen, Austin, TX USA
[8] Malibu Beach Recovery Ctr, Dept Addict Res & Therapy, Malibu, CA USA
[9] Domin Diagnost LLC, North Kingston, RI USA
[10] Dietary Res Fdn LLC, Durham, NH USA
[11] Calif State Univ, Dept Sociol, Turlock, CA USA
[12] Boston Univ, Sch Med, Dept Psychiat, Boston, VA USA
[13] Boston Univ, Sch Med, Dept Neurol, Boston, VA USA
[14] Boston Univ, Sch Med, Dept Anat & Neurobiol, Boston, VA USA
[15] Univ Texas San Antonio, Dept Management Sci & Stat, San Antonio, TX USA
基金
美国国家卫生研究院;
关键词
level of educational attainment; relapse rates; reward circuitry; reward deficiency syndrome (RDS); dopaminergic pathways; cognition; decision-making; micronutrient supplementation; REWARD DEFICIENCY SYNDROME; VITAMIN-MINERAL SUPPLEMENTATION; PLACEBO-CONTROLLED TRIAL; DOPAMINE-RECEPTOR GENE; YOUNG-ADULT PRISONERS; ALLELIC ASSOCIATION; COCAINE DEPENDENCE; POLYDRUG ABUSERS; LEAD-EXPOSURE; BIRTH-WEIGHT;
D O I
10.3810/psm.2014.05.2065
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
It is well known that athletes and other individuals who have suffered painful injuries are at increased risk for all reward deficiency syndrome (RDS) behaviors, including substance use disorder (SUD). Comparing patient demographics and relapse rates in chemical dependence programs is pertinent because demographics may affect outcomes. Increased risk for relapse and lower academic achievement were found to have a significant association in recent outcome data from a holistic treatment center (HTC) located in North Miami Beach, FL. Relapse outcomes from the Drug Addiction Treatment Outcome Study (DATOS; n = 1738) and HTC (n = 224) were compared for a 12-month period. Post-discharge relapse was reported by 26% of HTC patients and 58% of patients in DATOS. When broken out by education level-less than high school, high school diploma, college degree, and graduate degree-HTC patient relapse was 50%, 36%, 33%, and 16%, respectively, and demonstrated an inverse linear association (F = 5.702; P = 0.017). Looking at DATOS patient relapse rates broken down by educational grades/years completed, patients who attended school between 7th grade and 4 years of college also demonstrated an inverse linear association (F = 5.563; P = 0.018). Additionally, the lowest performers, patients who reported their academic performance as "not so good,"had the highest relapse (F = 4.226; P = 0.04). Albeit certain limitations, compared with DATOS patients, HTC patients produced significantly larger net differences in relapse rates (X-2 = 84.09; P = 0.0001), suggesting that other variables, such as the treatment model may also affect patient relapse. Our results implicate the use of vitamin and mineral supplements coupled with a well-researched natural dopamine agonist nutrient therapy; both have been shown to improve cognition and behavior, and thus academic achievement. That relapse is highest among addicts who have less education and who report lower grades is a factor that can be useful when considering treatment type and controlled for when comparing treatment outcomes.
引用
收藏
页码:130 / 145
页数:16
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