Comparison of anal cancer screening strategies including standard anoscopy, anal cytology, and HPV genotyping in HIV-positive men who have sex with men

被引：41

作者：

Pernot, Simon ^{[1
,2
]}

Boucheron, Pauline ^{[3
]}

Pere, Helene ^{[2
,4
]}

Lucas, Marie-Laure ^{[5
]}

Veyer, David ^{[2
,4
]}

Fathallah, Nadia ^{[6
]}

de Parades, Vincent ^{[6
]}

Pavie, Juliette ^{[5
]}

Netter, Jeanne ^{[1
]}

Collias, Lio ^{[5
]}

Taieb, Julien ^{[1
,2
]}

Grabar, Sophie ^{[2
,3
]}

Weiss, Laurence ^{[2
,5
]}

机构：

[1] Georges Pompidou European Hosp, AP HP, Dept Hepato Gastroenterol & Digest Oncol, Paris, France

[2] Univ Paris 05, Sorbonne Paris Cite, Paris, France

[3] Cochin Hotel Dieu Hosp, AP HP, Dept Biostat & Epidemiol, Paris, France

[4] Georges Pompidou European Hosp, AP HP, Dept Virol, Paris, France

[5] Georges Pompidou European Hosp, AP HP, Dept Clin Immunol, Paris, France

[6] St Joseph Hosp, Dept Proctol, Paris, France

来源：

BRITISH JOURNAL OF CANCER | 2018年 / 119卷 / 03期

关键词：

SQUAMOUS INTRAEPITHELIAL LESIONS; HUMAN-PAPILLOMAVIRUS; INFECTED MEN; NEOPLASIA; PERFORMANCE; PREVALENCE; GUIDELINES; CARCINOMA;

D O I：

10.1038/s41416-018-0176-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BACKGROUND: There is no consensus on screening strategy of high-grade intraepithelial neoplasia (HGAIN). Guidelines range from clinical examination with digital anorectal examination followed by standard anoscopy (SA), to anal cytology (Pap)+/- HPV genotyping. We compared screening strategy yields based on Pap, SA, and HPV-16 genotyping alone or in combination in HIV-MSM. METHODS: Pap, SA, and HPV-16 genotyping were performed in all HIV-MSM attending a first anal cancer screening consultation in Paris, France. High-resolution anoscopy, the gold standard to detect HGAIN, was performed in the case of HPV-16 positivity or abnormal cytology. Yield was defined as the number of patients with HGAIN relative to the total number of patients screened. RESULTS: On 212 patients, the complete strategy (SA + Pap + HPV genotyping) yield (12.7%) was significantly higher than that of SA (3.3%, p < 0.001) and HPV-16 alone (6.6%, p < 0.05). Although none of the other strategies were significantly different from the complete strategy, Pap + HPV-16 and Pap + SA had closer yields (about 11%), with OR = 0.83 (95% CI [0.44; 1.57]) and 0.87 (95% CI [0.46; 1.64]), respectively. CONCLUSIONS: Pap combined with HPV-16 genotyping or SA tended towards higher yields compared to Pap alone, and closer to that of the complete strategy.

引用

页码：381 / 386

页数：6

共 40 条

[1]

Aberg JA, 2014, CLIN INFECT DIS, V58, P1, DOI [10.1093/cid/cit665, 10.1093/cid/cit757]

[2] Determinants of macroscopic anal cancer and precancerous lesions in 1206 HIV-infected screened patients [J].