Influence of Selenium on the Production of T-2 Toxin by Fusarium poae

被引:17
作者
Cheng, Bolun [1 ]
Zhang, Yan [1 ,2 ]
Tong, Bei [1 ]
Yin, Hong [1 ,3 ]
机构
[1] Northwest Univ, Coll Life Sci, Xian 710069, Peoples R China
[2] Baoji Ctr Dis Control & Prevent, Baoji 721006, Peoples R China
[3] Northwest Univ, Key Lab Resource Biol & Biotechnol Western Chin, Minist Educ, Xian 710069, Peoples R China
关键词
Selenium; Fusarium poae; T-2; toxin; Kashin-Beck disease; KASHIN-BECK DISEASE; CHINA; CHONDROCYTES; DAMAGE; DIET;
D O I
10.1007/s12011-016-0900-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The objective of this study was to investigate the effects of selenium on the production of T-2 toxin by a Fusarium poae strain cultured in a synthetic medium containing different concentrations of selenium. The T-2 toxin contents in fermentative products were evaluated by a high performance liquid chromatography (HPLC). The results showed that the production of T-2 toxin was correlated with the concentration of selenium added to the medium. In all three treatments, the addition of 1 mg/L selenium to the medium resulted in a lower toxin yield than the control (0 mg/L); the yield of the toxin began to increase when selenium concentration was 10 mg/L, while it decreased again at 20 mg/L. In summary, T-2 toxin yield in the fermentative product was affected by the addition of selenium to the medium, and a selenium concentration of 20 mg/L produced the maximum inhibitory effect of T-2 toxin yield in the fermentative product of F. poae.
引用
收藏
页码:147 / 152
页数:6
相关论文
共 34 条
[1]   Oxidative Damage and Gene Expression Profile of Antioxidant Enzymes After T-2 Toxin Exposure in Mice [J].
Chaudhari, Manjari ;
Jayaraj, R. ;
Santhosh, S. R. ;
Rao, P. V. Lakshmana .
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2009, 23 (03) :212-221
[2]   T-2 toxin induces apoptosis, and selenium partly blocks, T-2 toxin induced apoptosis in chondrocytes through modulation of the Bax/Bcl-2 ratio [J].
Chen, JH ;
Chu, YL ;
Cao, JL ;
Yang, ZT ;
Guo, X ;
Wang, ZL .
FOOD AND CHEMICAL TOXICOLOGY, 2006, 44 (04) :567-573
[3]   Oxidant damage in Kashin-Beck disease and a rat Kashin-Beck disease model by employing T-2 toxin treatment under selenium deficient conditions [J].
Chen, Jing-hong ;
Xue, Senghai ;
Li, Siyuan ;
Wang, Zhi-lun ;
Yang, Haojie ;
Wang, Wei ;
Song, Daiqing ;
Zhou, Xiaorong ;
Chen, Chen .
JOURNAL OF ORTHOPAEDIC RESEARCH, 2012, 30 (08) :1229-1237
[4]  
China Environmental Monitoring Station, 1990, CHIN SOIL EL BACKGR
[5]   Osteo-Chondroprogenitor-Specific Deletion of the Selenocysteine tRNA Gene, Trsp, Leads to Chondronecrosis and Abnormal Skeletal Development: A Putative Model for Kashin-Beck Disease [J].
Downey, Charlene M. ;
Horton, Chelsea R. ;
Carlson, Bradley A. ;
Parsons, Trish E. ;
Hatfield, Dolph L. ;
Hallgrimsson, Benedikt ;
Jirik, Frank R. .
PLOS GENETICS, 2009, 5 (08)
[6]   Histopathology of chondronecrosis development in knee articular cartilage in a rat model of Kashin-Beck disease using T-2 toxin and selenium deficiency conditions [J].
Guan, Fang ;
Li, Siyuan ;
Wang, Zhi-lun ;
Yang, Haojie ;
Xue, Senghai ;
Wang, Wei ;
Song, Daiqing ;
Zhou, Xiaorong ;
Zhou, Wang ;
Chen, Jing-hong ;
Caterson, Bruce ;
Hughes, Clare .
RHEUMATOLOGY INTERNATIONAL, 2013, 33 (01) :157-166
[7]   Recent advances in the research of an endemic osteochondropathy in China: Kashin-Beck disease [J].
Guo, X. ;
Ma, W. -J. ;
Zhang, F. ;
Ren, F. -L. ;
Qu, C. -J. ;
Lammi, M. J. .
OSTEOARTHRITIS AND CARTILAGE, 2014, 22 (11) :1774-1783
[8]  
GUO X, 2001, INT ORTHOP, V25, P147
[9]  
[郭雄 Guo Xiong], 2008, [西安交通大学学报. 医学版, Journal of Xi'an Jiaotong University. Medical Sciences], V29, P481
[10]  
Haubruge E, 2003, MT RES DEV, V23, P284, DOI 10.1659/0276-4741(2003)023[0284:MISBHV]2.0.CO