Effects of lactic acid bacteria on binding and absorption of mutagenic heterocyclic amines

被引:25
作者
Terahara, M [1 ]
Meguro, S [1 ]
Kaneko, T [1 ]
机构
[1] Meiji Milk Prod Co Ltd, Cent Res Inst, Tokyo 189, Japan
关键词
Lactobacillus delbrueckii subsp. bulgaricus 2038; Streptococcus thermophilus 1131; small intestine;
D O I
10.1271/bbb.62.197
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Effects of binding heterocyclic amines to cells of lactic acid bacteria on theirs absorption were investigated. Cells of Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131 bind both 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx). The binding of strain 1131 cells to Trp-P-1 was maximum in the pHs from 4 to 8, but strain 2038 cells bound Trp-P-1 and MeIQx only slightly at pH 7. We investigated the absorption of heterocyclic amines by the small intestine of F344 rats in the presence of these bacterial cells, using an in situ loop technique. The absorption of Trp-P-1 by the small intestine was significantly lower in the presence of strain 1131 cells than in the absence of the cells, but the presence of strain 2038 cells had no effect on Trp-P-1 absorption. Perhaps strain 1131 cells bind to Trp-P-1 at the same pH as that of the small intestine (pH 6-7) and thus decrease its absorption.
引用
收藏
页码:197 / 200
页数:4
相关论文
共 32 条
[1]   DISTRIBUTION OF RADIOLABELED [2-C-14]IQ AND MEIQX IN THE MOUSE [J].
ALLDRICK, AJ ;
ROWLAND, IR .
TOXICOLOGY LETTERS, 1988, 44 (1-2) :183-190
[2]   ANTI-TUMOR COMPONENT(S) OF YOGURT - FRACTIONATION [J].
AYEBO, AD ;
SHAHANI, KM ;
DAM, R .
JOURNAL OF DAIRY SCIENCE, 1981, 64 (12) :2318-2323
[3]  
BRUNNER H, 1974, MAYO CLIN PROC, V49, P851
[4]   INHIBITION OF 2-AMINO-3-METHYLIMIDAZO[4,5-F]QUINOLINE (IQ) DNA-BINDING BY CHLOROPHYLLIN - STUDIES OF ENZYME-INHIBITION AND MOLECULAR-COMPLEX FORMATION [J].
DASHWOOD, R ;
GUO, D .
CARCINOGENESIS, 1992, 13 (07) :1121-1126
[6]   INTAKE OF FOODS AND NUTRIENTS AND CANCER OF THE EXOCRINE PANCREAS - A POPULATION-BASED CASE-CONTROL STUDY IN THE NETHERLANDS [J].
DEMESQUITA, HBB ;
MAISONNEUVE, P ;
RUNIA, S ;
MOERMAN, CJ .
INTERNATIONAL JOURNAL OF CANCER, 1991, 48 (04) :540-549
[7]   MEAT, COOKING METHODS AND COLORECTAL-CANCER - A CASE-REFERENT STUDY IN STOCKHOLM [J].
DEVERDIER, MG ;
HAGMAN, U ;
PETERS, RK ;
STEINECK, G ;
OVERVIK, E .
INTERNATIONAL JOURNAL OF CANCER, 1991, 49 (04) :520-525
[8]   FOOD-BORNE HETEROCYCLIC AMINES - CHEMISTRY, FORMATION, OCCURRENCE AND BIOLOGICAL-ACTIVITIES - A LITERATURE-REVIEW [J].
EISENBRAND, G ;
TANG, W .
TOXICOLOGY, 1993, 84 (1-3) :1-82
[9]  
GOLDBOHM RA, 1994, CANCER RES, V54, P718
[10]   EFFECT OF DIET AND LACTOBACILLUS-ACIDOPHILUS SUPPLEMENTS ON HUMAN FECAL BACTERIAL ENZYMES [J].
GOLDIN, BR ;
SWENSON, L ;
DWYER, J ;
SEXTON, M ;
GORBACH, SL .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1980, 64 (02) :255-261