Central 5-HT1A receptors:: Regional distribution and functional characteristics

被引：93

作者：

Lanfumey, L ^{[1
]}

Hamon, M ^{[1
]}

机构：

[1] Univ Paris 06, INSERM, U288, F-75634 Paris 13, France

来源：

NUCLEAR MEDICINE AND BIOLOGY | 2000年 / 27卷 / 05期

关键词：

5-hydroxytryptamine; receptors; raphe; hippocampus; transduction; depression;

D O I：

10.1016/S0969-8051(00)00107-4

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Among the multiple receptors for serotonin identified to date, the 5-hydroxytryptamine (5-HT)(1A) type is among the best known because selective ligands have been available for more than 15 years. Radioactive derivatives allowed the demonstration of the presence of 5-HT1A binding sites mainly in the limbic areas and the raphe nuclei in the brain, where they correspond to postsynaptic receptors and "presynaptic" autoreceptors, respectively. This review article summarizes key data on the molecular, pharmacological, and differential functional properties of pre- versus postsynaptic 5-HT1A receptors. NUCL MED BIOL 27;5:429-435, 2000. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：429 / 435

页数：7

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