Septal-lateral annnular cinching perturbs basal left ventricular transmural strains

被引:9
作者
Nguyen, Tom C.
Cheng, Allen
Tibayan, Frederick A.
Liang, David
Daughters, George T.
Ingels, Neil B., Jr.
Miller, David Craig [1 ]
机构
[1] Stanford Univ, Sch Med, Dept Cardiothorac Surg, Falk Cardiovasc Res Ctr, Stanford, CA 94305 USA
[2] Div Cardiovasc Med, Stanford, CA USA
[3] Palo Alto Med Fdn, Inst Res, Palo Alto, CA USA
关键词
mitral regurgitation; schemic mitral regurgitation; mitral annutoplasty; myocardial ischemia; surgery; myocardial strain;
D O I
10.1016/j.ejcts.2006.12.019
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: Septal-lateral annular cinching ('SLAC') corrects both acute and chronic ischemic mitral regurgitation in animal experiments, which has led to the development of therapeutic surgical and interventional strategies incorporating this concept (e.g., Edwards GeoForm ring, Myocor Coapsys (R), Ample Medical PS3). Changes in left ventricular (LV) transmural cardiac and fiber-sheet strains after SLAC, however, remain unknown. Methods: Eight normal sheep hearts had two triads of transmural radiopaque bead columns inserted adjacent to (anterobasal) and remote from (midlateral equatorial) the mitral annulus. Under acute, open chest conditions, 4D bead coordinates were obtained using videofluoroscopy before and after SLAC. Transmural systolic strains were calculated from bead displacements relative to local circumferential, longitudinal, and radial cardiac axes. Transmural cardiac strains were transformed into fiber-sheet coordinates (X-f, X-s, X-n) oriented along the fiber (f), sheet (s), and sheet-normal (n) axes using fiber (alpha) and sheet (beta) angle measurements. Results: SLAC markedly reduced (similar to 60%) septal.-lateral annular diameter at both end-diastole (ED) (2.5 +/- 0.3 to 1.0 +/- 0.3 cm, p = 0.001) and end-systole (ES) (2.4 +/- 0.4 to 1.0 +/- 0.3 cm, p = 0.001). In the LV watt remote from the mitral annulus, transmural systolic strains did not change. In the anterobasal region adjacent to the mitral annulus, ED watt thickness increased (p = 0.01) and systolic watt thickening was less in the epicardial (0.28 +/- 0.12 vs 0.20 +/- 0.06, p = 0.05) and midwall (0.36 +/- 0.24 vs 0.19 +/- 0.11, p = 0.04) LV layers. This impaired watt thickening was due to decreased systolic sheet thickening (0.20 +/- 0.8 to 0.12 +/- 0.07, p = 0.01) and sheet shear (-0.15 +/- 0.07 to -0.11 +/- 0.04, p = 0.02) in the epicardium and sheet extension (0.21 +/- 0.11 to 0.10 +/- 0.04, p = 0.03) in the midwall. Transmural systolic and remodeling strains in the lateral midwall (remote from the annulus) were unaffected. Conclusions: Although SLAC is an alluring concept to correct ischemic mitral regurgitation, these data suggest that extreme SLAC adversely effects systolic wall thickening adjacent to the mitral. annulus by inhibiting systolic sheet thickening, sheet shear, and sheet extension. Such alterations in LV strains could result in unanticipated deleterious remodeling and warrant further investigation. (c) 2007 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:423 / 429
页数:7
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