Synthesis of Acyclic Selenonucleoside Phosphonates as Potential Antiviral Agents

被引：8

作者：

Sahu, Pramod K. ^{[1
]}

Kim, Gyudong ^{[1
]}

Nayak, Akshata ^{[1
,2
]}

Ahn, Ji Yoon ^{[1
]}

Ha, Min Woo ^{[1
]}

Park, Cheonhyoung ^{[1
]}

Yu, Jinha ^{[1
]}

Park, Hyeung-geun ^{[1
]}

Jeong, Lak Shin ^{[1
]}

机构：

[1] Seoul Natl Univ, Pharmaceut Sci Res Inst, Coll Pharm, Seoul 151742, South Korea

[2] Ewha Womans Univ, Coll Pharm, Seoul 120750, South Korea

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 5卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

acyclic nucleoside phosphonates; antivirals; diselenides; selenoadefovir; selenotenofovir; NUCLEOTIDE ANALOGS; HEPATITIS-B; DERIVATIVES; INFECTIONS; MECHANISM; HIV;

D O I：

10.1002/ajoc.201500421

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

On the basis of potent antiviral activity of adefovir (1) and tenofovir (2), which are representative acyclic nucleoside phosphonates, bioisosteric acyclic selenonucleoside phosphonates seleno-adefovir (3) and seleno-tenofovir (4) were designed and synthesized from diethyl(iodomethyl)phosphonate (7) by using diselenide chemistry.

引用

页码：183 / 186

页数：4

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