Efficient Angiogenesis-Based Diabetic Wound Healing/Skin Reconstruction through Bioactive Antibacterial Adhesive Ultraviolet Shielding Nanodressing with Exosome Release

被引：476

作者：

Wang, Min ^{[1
]}

Wang, Chenggui ^{[2
,3
,5
]}

Chen, Mi ^{[1
]}

Xi, Yuewei ^{[1
]}

Cheng, Wei ^{[1
]}

Mao, Cong ^{[2
,3
]}

Xu, Tianzhen ^{[2
,3
]}

Zhang, Xingxing ^{[4
]}

Lin, Cai ^{[4
]}

Gao, Weiyang ^{[2
,3
]}

Guo, Yi ^{[6
]}

Lei, Bo ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Coll Stomatol, Key Lab Shaanxi Prov Craniofacial Precis Med Res, Xian 710000, Shaanxi, Peoples R China

[2] Wenzhou Med Univ, Affiliated Hosp 2, Key Lab Orthoped Zhejiang Prov, Wenzhou 325027, Peoples R China

[3] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325027, Peoples R China

[4] Wenzhou Med Univ, Dept Burn, Affiliated Hosp 1, Wenzhou 325000, Peoples R China

[5] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Orthoped Surg, Hangzhou 310009, Zhejiang, Peoples R China

[6] Univ Michigan, Dept Biol & Mat Sci, Ann Arbor, MI 48109 USA

来源：

ACS NANO | 2019年 / 13卷 / 09期

基金：

中国国家自然科学基金;

关键词：

bioactive scaffolds; antibacterial property; UV-shielding; hemostasis; angiogenesis; diabetic wound healing; STEM-CELLS; ANIMAL-MODELS; HYDROGEL; DELIVERY; NANOPARTICLES; DRESSINGS; PROMOTE; MATRIX; VASCULARIZATION; TRANSPARENT;

D O I：

10.1021/acsnano.9b03656

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Diabetic wound healing and angiogenesis remain a worldwide challenge for both clinic and research. The use of adipose stromal cell derived exosomes delivered by bioactive dressing provides a potential strategy for repairing diabetic wounds with less scar formation and fast healing. In this study, we fabricated an injectable adhesive thermosensitive multifunctional polysaccharide-based dressing (FEP) with sustained pH-responsive exosome release for promoting angiogenesis and diabetic wound healing. The FEP dressing possessed multifunctional properties including efficient antibacterial activity/multidrug-resistant bacteria, fast hemostatic ability, self-healing behavior, and tissue-adhesive and good UV-shielding performance. FEP@exosomes (FEP@exo) can significantly enhance the proliferation, migration, and tube formation of endothelial cells in vitro. In vivo results from a diabetic full-thickness cutaneous wound model showed that FEPpexo dressing accelerated the wound healing by stimulating the angiogenesis process of the wound tissue. The enhanced cell proliferation, granulation tissue formation, collagen deposition, remodeling, and re-epithelialization probably lead to the fast healing with less scar tissue formation and skin appendage regeneration. This study showed that combining bioactive molecules into multifunctional dressing should have great potential in achieving satisfactory healing in diabetic and other vascular-impaired related wounds.

引用

页码：10279 / 10293

页数：15

共 76 条

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