Anterior Temporal Atrophy and Posterior Progression in Patients with Parkinson's Disease

被引:23
作者
Potgieser, Adriaan R. E. [1 ,2 ,3 ]
van der Hoorn, Anouk [1 ,2 ]
Meppelink, Anne Marthe [1 ,2 ]
Teune, Laura K. [1 ,2 ]
Koerts, Janneke [4 ]
de Jong, Bauke M. [1 ,2 ]
机构
[1] Univ Groningen, Univ Med Ctr Groningen, Dept Neurol, NL-9700 RB Groningen, Netherlands
[2] Univ Groningen, Univ Med Ctr Groningen, Dept Neuroimaging Ctr, NL-9700 RB Groningen, Netherlands
[3] Univ Groningen, Univ Med Ctr Groningen, Dept Neurosurg, NL-9700 RB Groningen, Netherlands
[4] Univ Groningen, Dept Clin & Dev Neuropsychol, Groningen, Netherlands
关键词
Parkinson's disease; Voxel-based morphometry; Atrophy; VOXEL-BASED MORPHOMETRY; GRAY-MATTER; COGNITIVE DYSFUNCTION; VISUAL HALLUCINATIONS; LIMBIC SYSTEM; F-18-DOPA PET; HUMAN BRAIN; DEMENTIA; CORTEX; SEGMENTATION;
D O I
10.1159/000363245
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Parkinson's disease (PD) is characterized by specific motor and nonmotor impairments. This suggests that PD is characterized by disease-specific regional cortical atrophy. Given the change of symptoms overtime, a concurrent increase in regional atrophy may further be assumed to reflect the dynamic process of disease progression. Methods: In this study we retrospectively collected T1-weighted MRI scans from previous studies performed in our center, enabling the comparison of gray matter atrophy in 77 PD patients with 87 controls using voxel-based morphometry (VBM). This large VBM analysis provided the opportunity to investigate cortical atrophy in relation with disease progression. Results: We found significant PD-related reductions of gray matter density bilaterally in the anterior temporal cortex, the left inferior frontal and left extrastriate visual cortex, independent from normal aging. The anterior temporal cortex did not show major progression, whereas particularly the posterior parts of the lateral temporal cortex and adjacent extrastriate visual cortex occurred at a later stage of disease. Conclusions: Temporal pole atrophy as an early sign of PD is consistent with the PD pathology classification of Braak. The initial anterior temporal atrophy with spread to occipitotemporal and posterior parietal regions may subserve 'emotion-based' sensorimotor transformations and deficits in the visual domain, respectively, which may be regarded as prennotor symptoms. (C) 2014 S. Karger AG, Basel.
引用
收藏
页码:125 / 132
页数:8
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