HOAc catalyzed three-component reaction for the synthesis of 3,3′-(arylmethylene)bis(1H-indoles)

被引：3

作者：

Li, Heng ^{[1
]}

Zhu, Yan ^{[1
]}

Jiang, Cong ^{[1
]}

Wei, Jia ^{[1
]}

Liu, Ping ^{[1
]}

Sun, Peipei ^{[1
]}

机构：

[1] Nanjing Normal Univ, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Sch Chem & Mat Sci, Jiangsu Prov Key Lab Mat Cycle Proc & Pollut Cont, Nanjing 210023, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2022年 / 20卷 / 16期

基金：

中国国家自然科学基金;

关键词：

ONE-POT SYNTHESIS; INDOLE ALKALOIDS; 3+2 ANNULATION; ARYLATION; FUNCTIONALIZATION; CYCLIZATION; ACTIVATION; DISCOVERY; ALDEHYDES; PROGRESS;

D O I：

10.1039/d2ob00395c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient HOAc catalyzed three-component reaction of 2-(arylethynyl)anilines with arylaldehydes has been achieved, which leads to the generation of 3,3 '-(arylmethylene)bis(1H-indoles) with good to excellent yields and high regioselectivity under transition-metal-free conditions. Four new C-C and C-N bonds were effectively formed in a one-pot procedure. Subsequent research on the reaction mechanism indicated that the reaction likely involved the processes of intramolecular cyclization and cascade intermolecular dehydration condensation.

引用

页码：3365 / 3374

页数：10

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