Methylphenidate: Its pharmacology and uses

被引:0
作者
Challman, TD
Lipsky, JJ
机构
[1] Mayo Clin & Mayo Fdn, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN 55905 USA
[2] Mayo Clin & Mayo Fdn, Dept Pediat & Adolescent Med, Rochester, MN 55905 USA
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中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Methylphenidate is a commonly used medication in the United States. This central nervous system stimulant has a mechanism of action distinct from that of amphetamine, The Food and Drug Administration has approved methylphenidate for the treatment of attention-deficit/hyperactivity disorder and narcolepsy, Treatment with methylphenidate has been advocated in patients with traumatic brain injury and stroke, cancer patients, and those with human immunodeficiency virus infection. Placebo-controlled trials have documented its efficacy as an adjunctive agent in the treatment of depression and pain. This article reviews the current understanding of the mechanism of action and efficacy of methylphenidate in various clinical conditions.
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页码:711 / 721
页数:11
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共 188 条
[1]  
*AM PSYCH ASS, 1994, DIAGN STAT MAN MENT, P78
[2]   CLINICAL EFFECTS OF METHYLPHENIDATE AND THIORIDAZINE IN INTELLECTUALLY SUBAVERAGE CHILDREN [J].
AMAN, MG ;
MARKS, RE ;
TURBOTT, SH ;
WILSHER, CP ;
MERRY, SN .
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 1991, 30 (02) :246-256
[3]   METHYLPHENIDATE AND THIORIDAZINE IN THE TREATMENT OF INTELLECTUALLY SUBAVERAGE CHILDREN - EFFECTS ON COGNITIVE-MOTOR PERFORMANCE [J].
AMAN, MG ;
MARKS, RE ;
TURBOTT, SH ;
WILSHER, CP ;
MERRY, SN .
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 1991, 30 (05) :816-824
[4]  
ANGRIST B, 1992, J CLIN PSYCHOPHARM, V12, P268
[5]   NONLINEAR KINETICS OF THREO-METHYLPHENIDATE ENANTIOMERS IN A PATIENT WITH NARCOLEPSY AND IN HEALTHY-VOLUNTEERS [J].
AOYAMA, T ;
KOTAKI, H ;
SASAKI, T ;
SAWADA, Y ;
HONDA, Y ;
IGA, T .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1993, 44 (01) :79-84
[6]   Pharmacodynamic modeling for change of locomotor activity by methylphenidate in rats [J].
Aoyama, T ;
Yamamoto, K ;
Kotaki, H ;
Sawada, Y ;
Iga, T .
PHARMACEUTICAL RESEARCH, 1997, 14 (11) :1601-1606
[7]   STEREOSPECIFIC DISTRIBUTION OF METHYLPHENIDATE ENANTIOMERS IN RAT-BRAIN - SPECIFIC BINDING TO DOPAMINE REUPTAKE SITES [J].
AOYAMA, T ;
KOTAKI, H ;
SAWADA, Y ;
IGA, T .
PHARMACEUTICAL RESEARCH, 1994, 11 (03) :407-411
[8]   Pharmacokinetics and pharmacodynamics of methylphenidate enantiomers in rats [J].
Aoyama, T ;
Kotaki, H ;
Sawada, Y ;
Iga, T .
PSYCHOPHARMACOLOGY, 1996, 127 (02) :117-122
[9]   KINETIC-ANALYSIS OF ENANTIOMERS OF THREO-METHYLPHENIDATE AND ITS METABOLITE IN 2 HEALTHY-SUBJECTS AFTER ORAL-ADMINISTRATION AS DETERMINED BY A GAS-CHROMATOGRAPHIC MASS-SPECTROMETRIC METHOD [J].
AOYAMA, T ;
KOTAKI, H ;
HONDA, Y ;
NAKAGAWA, F .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1990, 79 (06) :465-469
[10]  
ASKINAZI C, 1986, J CLIN PSYCHIAT, V47, P467