Biophysical characterization of lectin-glycan interactions for therapeutics, vaccines and targeted drug delivery

被引：14

作者：

Christie, Michelle P. ^{[2
]}

Toth, Istvan ^{[2
,3
]}

Simerska, Pavla ^{[1
,2
]}

机构：

[1] Univ Queensland, Sch Chem & Mol Biosci, St Lucia, Qld 4072, Australia

[2] Univ Queensland, Sch Chem & Mol Biosci, St Lucia, Qld 4072, Australia

[3] Univ Queensland, Pharm Australia Ctr Excellence, Sch Pharm, Woolloongabba, Qld 4102, Australia

来源：

FUTURE MEDICINAL CHEMISTRY | 2014年 / 6卷 / 18期

关键词：

FRONTAL AFFINITY-CHROMATOGRAPHY; ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY; STD NMR-SPECTROSCOPY; LIGAND-BINDING; FLUORESCENCE POLARIZATION; CARBOHYDRATE SPECIFICITY; LIQUID-CHROMATOGRAPHY; PROTEIN GLYCOFORMS; STRUCTURAL BASIS; HIGH-THROUGHPUT;

D O I：

10.4155/fmc.14.130

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Lectin-glycan interactions play a role in biological processes, host-pathogen interactions and in disease. A more detailed understanding of these interactions is not only useful for the elucidation of their biological function but can also be applied in immunology, drug development and delivery and diagnostics. We review some commonly used biophysical techniques for studying lectin-glycan interactions; namely: frontal affinity chromatography, glycan/lectin microarray, surface plasmon resonance, electrochemical impedance spectroscopy, isothermal titration calorimetry, fluorescent assays, enzyme linked lectin sorbent assay and saturation transfer difference nuclear magnetic resonance spectroscopy. Each method is evaluated on efficiency, cost and throughput. We also consider the advantages and limitations of each technique and provide examples of their application in biology, drug discovery and delivery, immunology, glycoprofiling and biosensing.

引用

页码：2113 / 2129

页数：17

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