Radical-Induced Metal and Solvent-Free Cross-Coupling Using TBAI-TBHP: Oxidative Amidation of Aldehydes and Alcohols with N-Chloramines via C-H Activation

被引：82
|
作者：
Achar, Tapas Kumar [1 ]
Mal, Prasenjit [1 ]
机构：
[1] NISER, Sch Chem Sci, Inst Phys Campus, Bhubaneswar 751005, Odisha, India
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 80卷 / 01期
关键词：
AMIDE BOND FORMATION; ATMOSPHERIC-PRESSURE; MILD AMIDATION; AMINES; MICROWAVE; PEPTIDE; AMINOCARBONYLATION; MECHANOCHEMISTRY; REDUCTION; CATALYSIS;
D O I：
10.1021/jo502464n
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A solvent-free cross-coupling method for oxidative amidation of aldehydes and alcohols via a metal-free radial pathway has been demonstrated. The proposed methodology uses the TBAI-TBHP combination which efficiently induces metal-free C-H activation of aldehydes under neat conditions at 50 degrees C or ball-milling conditions at room temperature.
引用
收藏
页码：666 / 672
页数：7
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