Radical-Induced Metal and Solvent-Free Cross-Coupling Using TBAI-TBHP: Oxidative Amidation of Aldehydes and Alcohols with N-Chloramines via C-H Activation

被引：82

作者：

Achar, Tapas Kumar ^{[1
]}

Mal, Prasenjit ^{[1
]}

机构：

[1] NISER, Sch Chem Sci, Inst Phys Campus, Bhubaneswar 751005, Odisha, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 80卷 / 01期

关键词：

AMIDE BOND FORMATION; ATMOSPHERIC-PRESSURE; MILD AMIDATION; AMINES; MICROWAVE; PEPTIDE; AMINOCARBONYLATION; MECHANOCHEMISTRY; REDUCTION; CATALYSIS;

D O I：

10.1021/jo502464n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A solvent-free cross-coupling method for oxidative amidation of aldehydes and alcohols via a metal-free radial pathway has been demonstrated. The proposed methodology uses the TBAI-TBHP combination which efficiently induces metal-free C-H activation of aldehydes under neat conditions at 50 degrees C or ball-milling conditions at room temperature.

引用

页码：666 / 672

页数：7