Synthesis of Novel 7-methylene-6,7-dihyrobenzo[f]Benzo[4,5]Imidazo[1,2-d][1,4]Oxazepines via Base-mediated Regioselective Intramolecular Hydroamination

被引：6

作者：

Yavari, Hossein ^{[1
]}

Alinezhad, Heshmatollah ^{[1
]}

Shafiee, Abbas ^{[2
,3
]}

机构：

[1] Univ Mazandaran, Fac Chem, Babolsr, Iran

[2] Univ Tehran Med Sci, Fac Pharm, Dept Med Chem, Tehran 14176, Iran

[3] Univ Tehran Med Sci, Pharmaceut Sci Res Ctr, Tehran 14176, Iran

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2017年 / 54卷 / 04期

关键词：

PHARMACOLOGICAL EVALUATION; BENZOXAZEPINE DERIVATIVES; ALKYNES; AGENTS; EFFICIENT; ALKENES; OLEFINS; AMINES;

D O I：

10.1002/jhet.2833

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A versatile and transition metal-free approach for the synthesis of new 7-methylene-6,7-dihyrobenzo[f]benzo[4,5]imidazo[1,2-d][1,4]oxazepines were developed by an efficient 7-exo-dig regioselective hydroamination of 2-(2-(prop-2-yn-1-yloxy)phenyl)-1H-benzo[d]imidazole in the presence of potassium carbonate in DMF at 90 degrees C.

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收藏

页码：2393 / 2396

页数：4

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