Diversity-oriented synthesis of spirothiazolidinediones and their biological evaluation

被引：17

作者：

Kotha, Sambasivarao ^{[1
]}

Sreevani, Gaddamedi ^{[1
]}

Dzhemileva, Lilya U. ^{[2
,3
]}

Yunusbaeva, Milyausha M. ^{[2
]}

Dzhemilev, Usein M. ^{[2
]}

D'yakonov, Vladimir A. ^{[2
]}

机构：

[1] Indian Inst Technol, Dept Chem, Mumbai 400076, Maharashtra, India

[2] Russian Acad Sci, Inst Petrochem & Catalysis, Lab Catalyt Synth, Prospect Octyabrya 141, Ufa 450075, Russia

[3] Bashkir State Med Univ, Dept Immunol & Human Reprod Hlth, Lenin St 3, Ufa 450003, Russia

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 15卷

基金：

俄罗斯基础研究基金会;

关键词：

apoptosis; biologically active; 2+2+2] cycloaddition; flow cytometry; spiro thiazolidinedione; CATALYZED 2+2+2 CYCLOADDITION; ANTITUMOR-ACTIVITY; DERIVATIVES; THIAZOLIDINEDIONE; CHEMISTRY; CONSTRUCTION; INHIBITION; COMPLEXES; PRODUCTS; PROGRESS;

D O I：

10.3762/bjoc.15.269

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report a new synthetic approach to assemble spirothiazolidinediones via a [2 + 2 + 2] cyclotrimerization reaction and the derivatives were further functionalized through DA chemistry and click reaction. Using flow cytometry, it was shown for the first time that the new benzyl alcohol derivatives of thiazolidine-2,4-dione generated here are efficient apoptosis inducers in the HeLa, Hek293, U937, Jurkat, and K562 cell lines.

引用

页码：2774 / 2781

页数：8

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