Multi-component reactions 13:: Synthesis of γ-lactams as part of a multi-ring system via Ugi-4-centre-3-component reaction

被引：87

作者：

Hanusch-Kompa, C ^{[1
]}

Ugi, I ^{[1
]}

机构：

[1] Tech Univ Munich, Inst Organ Chem & Biochem, Lehrstuhl 1, D-85747 Garching, Germany

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 18期

关键词：

D O I：

10.1016/S0040-4039(98)00428-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Preparation of gamma-lactams 2a-h and 4a-h as part of a bi-or tri-cycle system in a one-pot Ugi-4-centre-3-component reaction (U-4C-3CR). A 3-keto or aldo acid was used as bifunctional educt. The application of C-protected amino acids as amine components enables an intramolecular condensation forming 2,6-piperazinediones 5a-h, connected to the gamma-lactam system (1,4-diazabicyclo[4.3.0]nonane-3,5,9-triones). (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2725 / 2728

页数：4

共 6 条

[1]

GROSS U, 1968, J PRAKT CHEM, V37, P192

[2] Synthesis of small and medium sized 2,2-disubstituted lactams via the ''intramolecular'' three component Ugi reaction [J].

Harriman, GCB .

TETRAHEDRON LETTERS, 1997, 38 (32) :5591-5594

[3] A solid-phase combinatorial method for the synthesis of novel 5- and 6-membered ring lactams [J].

Short, KM ;

Mjalli, AMM .

TETRAHEDRON LETTERS, 1997, 38 (03) :359-362

[4] MULTICOMPONENT REACTIONS IN ORGANIC-CHEMISTRY [J].

UGI, I ;

DOMLING, A ;

HORL, W .

ENDEAVOUR, 1994, 18 (03) :115-122

[5]

Ugi I., 1971, Isonitrile chemistry

[6]

UGI I, 1997, IN PRESS HETEROCYCLE

← 1 →