Anti-TNF Treatment in Crohn's Disease: Toward Tailored Therapy?

被引：7

作者：

D'Haens, Geert ^{[1
,2
]}

机构：

[1] Imelda GI Clin Res Ctr, Bonheiden, Belgium

[2] Univ Leuven, Louvain, Belgium

来源：

AMERICAN JOURNAL OF GASTROENTEROLOGY | 2010年 / 105卷 / 05期

关键词：

SCHEDULED MAINTENANCE TREATMENT; RANDOMIZED-TRIAL; INFLIXIMAB; ADALIMUMAB; ANTIBODIES;

D O I：

10.1038/ajg.2010.15

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Infliximab is a potent therapy for induction and maintenance of remission in Crohn's disease. Unfortunately, many patients lose response and/or develop allergic reactions caused by the chimeric antibody. By means of measuring the presence of antibodies against infliximab and the trough levels of the drug, it seems easier to predict whether patients will respond to intensified dose regimens or will rather benefit from a switch to alternative agents.

引用

页码：1140 / 1141

页数：2

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