Anti-TNF Treatment in Crohn's Disease: Toward Tailored Therapy?

被引：7
作者：
D'Haens, Geert [1 ,2 ]
机构：
[1] Imelda GI Clin Res Ctr, Bonheiden, Belgium
[2] Univ Leuven, Louvain, Belgium
来源：
AMERICAN JOURNAL OF GASTROENTEROLOGY | 2010年 / 105卷 / 05期
关键词：
SCHEDULED MAINTENANCE TREATMENT; RANDOMIZED-TRIAL; INFLIXIMAB; ADALIMUMAB; ANTIBODIES;
D O I：
10.1038/ajg.2010.15
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Infliximab is a potent therapy for induction and maintenance of remission in Crohn's disease. Unfortunately, many patients lose response and/or develop allergic reactions caused by the chimeric antibody. By means of measuring the presence of antibodies against infliximab and the trough levels of the drug, it seems easier to predict whether patients will respond to intensified dose regimens or will rather benefit from a switch to alternative agents.
引用
收藏
页码：1140 / 1141
页数：2
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  • [11] Scheduled maintenance treatment with infliximab is superior to episodic treatment for the healing of mucosal ulceration associated with Crohn's disease
    Rutgeerts, P
    Diamond, RH
    Bala, M
    Olson, A
    Lichtenstein, GR
    Bao, WH
    Patel, K
    Wolf, DC
    Safdi, M
    Colombel, JF
    Lashner, B
    Hanauer, SB
    [J]. GASTROINTESTINAL ENDOSCOPY, 2006, 63 (03) : 433 - 442
  • [12] Infliximab maintenance therapy for fistulizing Crohn's disease
    Sands, BE
    Anderson, FH
    Bernstein, CN
    Chey, WY
    Feagan, BG
    Fedorak, RN
    Kamm, MA
    Korzenik, JR
    Lashner, BA
    Onken, JE
    Rachmilewitz, D
    Rutgeerts, P
    Wild, G
    Wolf, DC
    Marsters, PA
    Travers, SB
    Blank, MA
    van Deventer, SJ
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (09) : 876 - 885
  • [13] Long-term outcome of treatment with infliximab in 614 patients with Crohn's disease: results from a single-centre cohort
    Schnitzler, F.
    Fidder, H.
    Ferrante, M.
    Noman, M.
    Arijs, I.
    Van Assche, G.
    Hoffman, I.
    Van Steen, K.
    Vermeire, S.
    Rutgeerts, P.
    [J]. GUT, 2009, 58 (04) : 492 - 500
  • [14] Maintenance therapy with certolizumab pegol for Crohn's disease
    Schreiber, Stefan
    Khaliq-Kareemi, Mani
    Lawrance, Ian C.
    Thomsen, Ole Ostergaard
    Hanauer, Stephen B.
    McColm, Juliet
    Bloomfield, Ralph
    Sandborn, William J.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2007, 357 (03) : 239 - 250
  • [15] Effectiveness of concomitant immunosuppressive therapy in suppressing the formation of antibodies to infliximab in Crohn's disease
    Vermeire, Severine
    Noman, Maja
    Van Assche, Gert
    Baert, Filip
    D'Haens, Geert
    Rutgeerts, Paul
    [J]. GUT, 2007, 56 (09) : 1226 - 1231
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