A Comprehensive Review on the Role of Non-Coding RNAs in the Pathophysiology of Bipolar Disorder

被引：21

作者：

Ghafouri-Fard, Soudeh ^{[1
]}

Badrlou, Elham ^{[1
]}

Taheri, Mohammad ^{[2
]}

Dursteler, Kenneth M. ^{[3
,4
]}

Beatrix Bruhl, Annette ^{[5
]}

Sadeghi-Bahmani, Dena ^{[5
,6
,7
]}

Brand, Serge ^{[5
,6
,8
,9
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Sch Med, Dept Med Genet, Tehran 65167198721, Iran

[2] Shahid Beheshti Univ Med Sci, Loghman Hakim Hosp, Skull Base Res Ctr, Tehran 65167198721, Iran

[3] Univ Basel, Div Subst Use Disorders, Psychiat Clin, CH-4002 Basel, Switzerland

[4] Univ Zurich, Hosp Psychiat, Ctr Addict Disorders, Dept Psychiat Psychotherapy & Psychosomat, CH-8001 Zurich, Switzerland

[5] Psychiat Univ Hosp Basel, Ctr Affect Stress & Sleep Disorders ZASS, CH-4002 Basel, Switzerland

[6] Kermanshah Univ Med Sci, Sleep Disorders Res Ctr, Kermanshah 67146, Iran

[7] Univ Alabama Birmingham, Dept Phys Therapy, Birmingham, AL 35294 USA

[8] Univ Basel, Dept Sport Exercise & Hlth, Div Sport Sci & Psychosocial Hlth, CH-4052 Basel, Switzerland

[9] Univ Tehran Med Sci, Sch Med, Tehran 25529, Iran

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 10期

关键词：

bipolar disorder; circRNA; miRNA; lncRNA; ANTERIOR CINGULATE; CIRCULAR RNAS; RISK-FACTORS; EXPRESSION; BRAIN; DYSREGULATION; SCHIZOPHRENIA; MICRORNAS; CORTEX; INDIVIDUALS;

D O I：

10.3390/ijms22105156

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aim: Bipolar disorder is a multifactorial disorder being linked with dysregulation of several genes. Among the recently acknowledged factors in the pathophysiology of bipolar disorder are non-coding RNAs (ncRNAs). Methods: We searched PubMed and Google Scholar databases to find studies that assessed the expression profile of miRNAs, lncRNAs and circRNAs in bipolar disorder. Results: Dysregulated ncRNAs in bipolar patients have been enriched in several neuron-related pathways such as GABAergic and glutamatergic synapses, morphine addiction pathway and redox modulation. Conclusion: Altered expression of these transcripts in bipolar disorder provides clues for identification of the pathogenesis of this disorder and design of targeted therapies for the treatment of patients.

引用

页数：27

共 63 条

[1] RNA-sequencing of the brain transcriptome implicates dysregulation of neuroplasticity, circadian rhythms and GTPase binding in bipolar disorder [J].

Akula, N. ;

Barb, J. ;

Jiang, X. ;

Wendland, J. R. ;

Choi, K. H. ;

Sen, S. K. ;

Hou, L. ;

Chen, D. T. W. ;

Laje, G. ;

Johnson, K. ;

Lipska, B. K. ;

Kleinman, J. E. ;

Corrada-Bravo, H. ;

Detera-Wadleigh, S. ;

Munson, P. J. ;

McMahon, F. J. .

MOLECULAR PSYCHIATRY, 2014, 19 (11) :1179-1185

[2] Exosomal secretion of a psychosis-altered miRNA that regulates glutamate receptor expression is affected by antipsychotics [J].

Amoah, Stephen K. ;

Rodriguez, Brian A. ;

Logothetis, Constantine N. ;

Chander, Praveen ;

Sellgren, Carl M. ;

Weick, Jason P. ;

Sheridan, Steven D. ;

Jantzie, Lauren L. ;

Webster, Maree J. ;

Mellios, Nikolaos .

NEUROPSYCHOPHARMACOLOGY, 2020, 45 (04) :656-665

[3] Neuropsin cleaves EphB2 in the amygdala to control anxiety [J].

Attwood, Benjamin K. ;

Bourgognon, Julie-Myrtille ;

Patel, Satyam ;

Mucha, Mariusz ;

Schiavon, Emanuele ;

Skrzypiec, Anna E. ;

Young, Kenneth W. ;

Shiosaka, Sadao ;

Korostynski, Michal ;

Piechota, Marcin ;

Przewlocki, Ryszard ;

Pawlak, Robert .

NATURE, 2011, 473 (7347) :372-U553

[4] The microRNA network is altered in anterior cingulate cortex of patients with unipolar and bipolar depression [J].

Azevedo, Joshua A. ;

Carter, Bradley S. ;

Meng, Fan ;

Turner, David L. ;

Dai, Manhong ;

Schatzberg, Alan F. ;

Barchas, Jack D. ;

Jones, Edward G. ;

Bunney, William E. ;

Myers, Richard M. ;

Akil, Huda ;

Watson, Stanley J. ;

Thompson, Robert C. .

JOURNAL OF PSYCHIATRIC RESEARCH, 2016, 82 :58-67

[5] MicroRNA Alterations in Induced Pluripotent Stem Cell-Derived Neurons from Bipolar Disorder Patients: Pathways Involved in Neuronal Differentiation, Axon Guidance, and Plasticity [J].

Bame, Monica ;

McInnis, Melvin G. ;

O'Shea, K. Sue .

STEM CELLS AND DEVELOPMENT, 2020, 29 (17) :1145-1159

[6] Dysregulation of miR-499, miR-708 and miR-1908 during a depression episode in bipolar disorders [J].

Banach, Ewa ;

Dmitrzak-Weglarz, Monika ;

Pawlak, Joanna ;

Kapelski, Pawel ;

Szczepankiewicz, Aleksandra ;

Rajewska-Rager, Aleksandra ;

Slopien, Agnieszka ;

Skibinska, Maria ;

Czerski, Piotr ;

Hauser, Joanna .

NEUROSCIENCE LETTERS, 2017, 654 :117-119

[7] Differential Expression of Exosomal microRNAs in Prefrontal Cortices of Schizophrenia and Bipolar Disorder Patients [J].

Banigan, Meredith G. ;

Kao, Patricia F. ;

Kozubek, James A. ;

Winslow, Ashley R. ;

Medina, Juan ;

Costa, Joan ;

Schmitt, Andrea ;

Schneider, Anja ;

Cabral, Howard ;

Cagsal-Getkin, Ozge ;

Vanderburg, Charles R. ;

Delalle, Ivana .

PLOS ONE, 2013, 8 (01)

[8] Dysregulation of miR-34a links neuronal development to genetic risk factors for bipolar disorder [J].

Bavamian, S. ;

Mellios, N. ;

Lalonde, J. ;

Fass, D. M. ;

Wang, J. ;

Sheridan, S. D. ;

Madison, J. M. ;

Zhou, Fen ;

Rueckert, E. H. ;

Barker, D. ;

Perlis, R. H. ;

Sur, M. ;

Haggarty, S. J. .

MOLECULAR PSYCHIATRY, 2015, 20 (05) :573-584

[9] MicroRNA dysregulation in manic and euthymic patients with bipolar disorder [J].

Camkurt, Mehmet Akif ;

Karababa, Ibrahim Fatih ;

Erdal, Mehmet Emin ;

Kandemir, Sultan Basmaci ;

Fries, Gabriel R. ;

Bayazit, Huseyin ;

Ay, Mustafa Ertan ;

Kandemir, Hasan ;

Ay, Ozlem Izci ;

Coskun, Salih ;

Cicek, Erdinc ;

Selek, Salih .

JOURNAL OF AFFECTIVE DISORDERS, 2020, 261 :84-90

[10] Circulating exosomal microRNAs in bipolar disorder [J].

Ceylan, Deniz ;

Tufekci, Kemal Ugur ;

Keskinoglu, Pembe ;

Genc, Sermin ;

Ozerdem, Aysegul .

JOURNAL OF AFFECTIVE DISORDERS, 2020, 262 :99-107

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