Novel a-ketoamide based diazeniumdiolates as hydrogen peroxide responsive nitric oxide donors with anti-lung cancer activity

被引：24
作者：
Fu, Junjie [1 ]
Han, Jing [2 ]
Meng, Tingting [1 ]
Hu, Jing [1 ,3 ]
Yin, Jian [1 ]
机构：
[1] Jiangnan Univ, Sch Biotechnol, Minist Educ, Key Lab Carbohydrate Chem & Biotechnol, Wuxi 214122, Jiangsu, Peoples R China
[2] Jiangsu Normal Univ, Sch Chem & Mat Sci, Jiangsu Key Lab Green Synthet Chem Funct Mat, Xuzhou 221116, Jiangsu, Peoples R China
[3] Jiangnan Univ, Wuxi Sch Med, Wuxi 214122, Jiangsu, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 86期
基金：
中国国家自然科学基金;
关键词：
OLEANOLIC ACID; PRODRUG; APOPTOSIS; MOLECULE; DELIVERY; DESIGN; PI;
D O I：
10.1039/c9cc05266f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel type of hydrogen peroxide (Hy(2)O(2))-activated diazeniumdiolate based on an a-ketoamide moietey was developed as a nitric oxide (NO) donor. KA-NO-4 inhibited lung cancer cells with submicromolar activity. The H2O2-responsive behaviour of KA-NO-4 was thoroughly investigated. The NO-centered mechanism of action of KA-NO-4 was intracellularly studied.
引用
收藏
页码：12904 / 12907
页数：4
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