Vascular Calcification in Chronic Kidney Disease: Diversity in the Vessel Wall

被引：61

作者：

Dube, Prabhatchandra ^{[1
]}

DeRiso, Armelle ^{[1
]}

Patel, Mitra ^{[1
]}

Battepati, Dhanushya ^{[1
]}

Khatib-Shahidi, Bella ^{[1
]}

Sharma, Himani ^{[1
]}

Gupta, Rajesh ^{[1
]}

Malhotra, Deepak ^{[1
]}

Dworkin, Lance ^{[1
]}

Haller, Steven ^{[1
]}

Kennedy, David ^{[1
]}

机构：

[1] Univ Toledo, Coll Med & Life Sci, Dept Med, Hlth Educ Bldg,RM 205,3000 Arlington Ave, Toledo, OH 43614 USA

来源：

BIOMEDICINES | 2021年 / 9卷 / 04期

基金：

美国国家卫生研究院;

关键词：

vascular calcification; chronic kidney disease; CKD; uremic toxins; hyperphosphatemia; vascular smooth muscle cells; VSMCs; macrophages; endothelium; SMOOTH-MUSCLE-CELLS; CORONARY-ARTERY CALCIFICATION; ENDOTHELIAL-MESENCHYMAL TRANSITION; ADVANCED ATHEROSCLEROTIC PLAQUES; MACROPHAGE-SPECIFIC LOSS; AORTIC CALCIFICATION; SHEAR-STRESS; URIC-ACID; CARDIOVASCULAR CALCIFICATION; EXTRACELLULAR VESICLES;

D O I：

10.3390/biomedicines9040404

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Vascular calcification (VC) is one of the major causes of cardiovascular morbidity and mortality in patients with chronic kidney disease (CKD). VC is a complex process expressing similarity to bone metabolism in onset and progression. VC in CKD is promoted by various factors not limited to hyperphosphatemia, Ca/Pi imbalance, uremic toxins, chronic inflammation, oxidative stress, and activation of multiple signaling pathways in different cell types, including vascular smooth muscle cells (VSMCs), macrophages, and endothelial cells. In the current review, we provide an in-depth analysis of the various kinds of VC, the clinical significance and available therapies, significant contributions from multiple cell types, and the associated cellular and molecular mechanisms for the VC process in the setting of CKD. Thus, we seek to highlight the key factors and cell types driving the pathology of VC in CKD in order to assist in the identification of preventative, diagnostic, and therapeutic strategies for patients burdened with this disease.

引用

页数：21

共 138 条

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