Regulate to reduce chemical mixture risk

被引:263
作者
Kortenkamp, Andreas [1 ]
Faust, Michael [2 ]
机构
[1] Brunel Univ London, Inst Environm Hlth & Soc, Uxbridge UB8 3PH, Middx, England
[2] Fasst & Backhaus Environm Consulting, Fahrenheitstr, Bremen, Germany
关键词
POLLUTANTS;
D O I
10.1126/science.aat9219
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Humans and wildlife are continuously exposed to multiple chemicals from different sources and via different routes, both simultaneously and in sequence. Scientific evidence for heightened toxicity from such mixtures is mounting, yet regulation is lagging behind. Ensuring appropriate regulation of chemical mixture risks will require stronger legal stimuli as well as close integration of different parts of the regulatory systems in order to meet the data and testing requirements for mixture risk assessment. © 2017 The Authors, some rights reserved.
引用
收藏
页码:224 / 226
页数:4
相关论文
共 14 条
[1]  
[Anonymous], 2009, REPORT EU COMMISSION
[2]  
[Anonymous], 2011, TOX ASS CHEM MIXT
[3]   Critical analysis of literature on low-dose synergy for use in screening chemical mixtures for risk assessment [J].
Boobis, Alan ;
Budinsky, Robert ;
Collie, Shanna ;
Crofton, Kevin ;
Embry, Michelle ;
Felter, Susan ;
Hertzberg, Richard ;
Kopp, David ;
Mihlan, Gary ;
Mumtaz, Moiz ;
Price, Paul ;
Solomon, Keith ;
Teuschler, Linda ;
Yang, Raymond ;
Zaleski, Rosemary .
CRITICAL REVIEWS IN TOXICOLOGY, 2011, 41 (05) :369-383
[4]   Mixtures of Chemical Pollutants at European Legislation Safety Concentrations: How Safe Are They? [J].
Carvalho, Raquel N. ;
Arukwe, Augustine ;
Ait-Aissa, Selim ;
Bado-Nilles, Anne ;
Balzamo, Stefania ;
Baun, Anders ;
Belkin, Shimshon ;
Blaha, Ludek ;
Brion, Francois ;
Conti, Daniela ;
Creusot, Nicolas ;
Essig, Yona ;
Ferrero, Valentina E. V. ;
Flander-Putrle, Vesna ;
Furhacker, Maria ;
Grillari-Voglauer, Regina ;
Hogstrand, Christer ;
Jonas, Adam ;
Kharlyngdoh, Joubert B. ;
Loos, Robert ;
Lundebye, Anne-Katrine ;
Modig, Carina ;
Olsson, Per-Erik ;
Pillai, Smitha ;
Polak, Natasa ;
Potalivo, Monica ;
Sanchez, Wilfried ;
Schifferli, Andrea ;
Schirmer, Kristin ;
Sforzini, Susanna ;
Sturzenbaum, Stephen R. ;
Softeland, Liv ;
Turk, Valentina ;
Viarengo, Aldo ;
Werner, Inge ;
Yagur-Kroll, Sharon ;
Zounkova, Radka ;
Lettieri, Teresa .
TOXICOLOGICAL SCIENCES, 2014, 141 (01) :218-233
[5]   Examining the feasibility of mixture risk assessment: A case study using a tiered approach with data of 67 pesticides from the Joint FAO/WHO Meeting on Pesticide Residues (JMPR) [J].
Evans, Richard M. ;
Scholze, Martin ;
Kortenkamp, Andreas .
FOOD AND CHEMICAL TOXICOLOGY, 2015, 84 :260-269
[6]   Human amniotic fluid contaminants alter thyroid hormone signalling and early brain development in Xenopus embryos [J].
Fini, Jean-Baptiste ;
Mughal, Bilal B. ;
Le Mevel, Sebastien ;
Leemans, Michelle ;
Lettmann, Melodie ;
Spirhanzlova, Petra ;
Affaticati, Pierre ;
Jenett, Arnim ;
Demeneix, Barbara A. .
SCIENTIFIC REPORTS, 2017, 7
[7]  
Joint Research Centre European Commission, 2018, SCI POL BRIEF SOM NO
[8]   A Method for Identifying Prevalent Chemical Combinations in the US Population [J].
Kapraun, Dustin F. ;
Wambaugh, John F. ;
Ring, Caroline L. ;
Tornero-Velez, Rogelio ;
Setzer, R. Woodrow .
ENVIRONMENTAL HEALTH PERSPECTIVES, 2017, 125 (08)
[10]   Low dose mixture effects of endocrine disrupters and their implications for regulatory thresholds in chemical risk assessment [J].
Kortenkamp, Andreas .
CURRENT OPINION IN PHARMACOLOGY, 2014, 19 :105-111