O/W Nanoemulsion After 15 Years of Preparation: A Suitable Vehicle for Pharmaceutical and Cosmetic Applications

被引：26

作者：

Maruno, Monica ^{[1
]}

da Rocha-Filho, Pedro Alves ^{[1
]}

机构：

[1] Univ Sao Paulo, Dept Pharmaceut Sci, Coll Pharmaceut Sci Ribeirao Preto, Sao Paulo, Brazil

来源：

JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY | 2010年 / 31卷 / 01期

关键词：

Droplet size; nanoemulsion; required HLB number; zeta potential; EMULSIFICATION; EMULSIONS;

D O I：

10.1080/01932690903123775

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The application of nanoemulsions is due to have good stability, uniform spreading and enhance active penetration upon skin. Nanometer emulsions can be obtained by low-energy emulsification method. The required hydrophilic and lipophilic balance indicates the better balance of emulsifier for optimum system emulsification. Emulsion stability is evidently controlled for the properties of the adsorbed layer formed in the surface of its globules, know as potential zeta. The aim of this work was to evaluate the oil/water nanoemulsion of formulation obtained after 15 years of preparation. The results suggested that the nanoemulsion have performed stability for many years.

引用

页码：17 / 22

页数：6

共 24 条

[1] Simultaneous conductivity and viscosity measurements as a technique to track emulsion inversion by the phase-inversion-temperature method [J].

Allouche, J ;

Tyrode, E ;

Sadtler, V ;

Choplin, L ;

Salager, JL .

LANGMUIR, 2004, 20 (06) :2134-2140

[2] 50 nm polystyrene particles via miniemulsion polymerization [J].

Anderson, CD ;

Sudol, ED ;

El-Aasser, MS .

MACROMOLECULES, 2002, 35 (02) :574-576

[3] The theory of emulsification, V [J].

Bancroft, WD .

JOURNAL OF PHYSICAL CHEMISTRY, 1913, 17 (06) :501-519

[4] SUBMICRON EMULSIONS AS COLLOIDAL DRUG CARRIERS FOR INTRAVENOUS ADMINISTRATION - COMPREHENSIVE PHYSICOCHEMICAL CHARACTERIZATION [J].

BENITA, S ;

LEVY, MY .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1993, 82 (11) :1069-1079

[5] Novel poloxamer-based nanoemulsions to enhance the intestinal absorption of active compounds [J].

Bruesewitz, Carsten ;

Schendler, Andreas ;

Funke, Adrian ;

Wagner, Torsten ;

Lipp, Ralph .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2007, 329 (1-2) :173-181

[6] Improvement of in vitro efficacy of a novel schistosomicidal drug by incorporation into nanoemulsion's [J].

Caldeira de Araújo, Savia ;

Alves de Mattos, Ana Carolina ;

Teixeira, Helder Ferreira ;

Zech Coelho, Paulo Marcos ;

Nelson, David Lee ;

de Oliveira, Monica Cristina .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2007, 337 (1-2) :307-315

[7] Functions of mixed emulsifiers and emulsifying waxes in dermatological lotions and creams [J].

Eccleston, GM .

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 1997, 123 :169-182

[8]

El-Aasser MS, 2004, JCT RES, V1, P21

[9] Nano-emulsion formation by emulsion phase inversion [J].

Fernandez, P ;

André, V ;

Rieger, J ;

Kühnle, A .

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2004, 251 (1-3) :53-58

[10] INFLUENCE OF MICROEMULSION PHASES ON THE PREPARATION OF FINE-DISPERSE EMULSIONS [J].

FORSTER, T ;

VONRYBINSKI, W ;

WADLE, A .

ADVANCES IN COLLOID AND INTERFACE SCIENCE, 1995, 58 (2-3) :119-149

← 1 2 3 →