Ubiquitous RNA-dependent RNA polymerase and gene silencing

被引：5

作者：

Birchler, James A. ^{[1
]}

机构：

[1] Univ Missouri, Div Biol Sci, Columbia, MO 65211 USA

来源：

GENOME BIOLOGY | 2009年 / 10卷 / 11期

基金：

美国国家科学基金会;

关键词：

DNA METHYLATION; DROSOPHILA; SUPPRESSION; SIRNA; INTERFERENCE; CHROMATIN; ELEGANS; PETUNIA; PLANTS; TRANS;

D O I：

10.1186/gb-2009-10-11-243

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The discovery of a novel RNA-dependent RNA polymerase activity with a eukaryote-wide distribution raises new questions about the roles and mechanisms of gene silencing by small RNAs.

引用

页数：3

共 21 条

[1] The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race [J].

Aravin, Alexei A. ;

Hannon, Gregory J. ;

Brennecke, Julius .

SCIENCE, 2007, 318 (5851) :761-764

[2]

Brennecke J, 2007, CELL, V128, P1089, DOI 10.1016/j.cell.2007.01.043

[3] Drosophila PIWI associates with chromatin and interacts directly with HP1a [J].

Brower-Toland, Brent ;

Findley, Seth D. ;

Jiang, Ling ;

Liu, Li ;

Yin, Hang ;

Dus, Monica ;

Zhou, Pei ;

Elgin, Sarah C. R. ;

Lin, Haifan .

GENES & DEVELOPMENT, 2007, 21 (18) :2300-2311

[4] Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans [J].

Fire, A ;

Xu, SQ ;

Montgomery, MK ;

Kostas, SA ;

Driver, SE ;

Mello, CC .

NATURE, 1998, 391 (6669) :806-811

[5] A slicer-mediated mechanism for repeat-associated siRNA 5′ end formation in Drosophila [J].

Gunawardane, Lalith S. ;

Saito, Kuniaki ;

Nishida, Kazumichi M. ;

Miyoshi, Keita ;

Kawamura, Yoshinori ;

Nagami, Tomoko ;

Siomi, Haruhiko ;

Siomi, Mikiko C. .

SCIENCE, 2007, 315 (5818) :1587-1590

[6] PAR-1, A GENE REQUIRED FOR ESTABLISHING POLARITY IN C-ELEGANS EMBRYOS, ENCODES A PUTATIVE SER/THR KINASE THAT IS ASYMMETRICALLY DISTRIBUTED [J].

GUO, S ;

KEMPHUES, KJ .

CELL, 1995, 81 (04) :611-620

[7] A species of small antisense RNA in posttranscriptional gene silencing in plants [J].

Hamilton, AJ ;

Baulcombe, DC .

SCIENCE, 1999, 286 (5441) :950-952

[8] RNA polymerase II is required for RNAi-dependent heterochromatin assembly [J].

Kato, H ;

Goto, DB ;

Martienssen, RA ;

Urano, T ;

Furukawa, K ;

Murakami, Y .

SCIENCE, 2005, 309 (5733) :467-469

[9] DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes [J].

Kuramochi-Miyagawa, Satomi ;

Watanabe, Toshiaki ;

Gotoh, Kengo ;

Totoki, Yasushi ;

Toyoda, Atsushi ;

Ikawa, Masahito ;

Asada, Noriko ;

Kojima, Kanako ;

Yamaguchi, Yuka ;

Ijiri, Takashi W. ;

Hata, Kenichiro ;

Li, En ;

Matsuda, Yoichi ;

Kimura, Tohru ;

Okabe, Masaru ;

Sakaki, Yoshiyuki ;

Sasaki, Hiroyuki ;

Nakano, Toru .

GENES & DEVELOPMENT, 2008, 22 (07) :908-917

[10] RNAi as random degradative PCR: siRNA primers convert mRNA into dsRNAs that are degraded to generate new siRNAs [J].

Lipardi, C ;

Wei, Q ;

Paterson, BM .

CELL, 2001, 107 (03) :297-307

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