Markers of acute kidney injury in children undergoing hematopoietic stem cell transplantation

被引：8

作者：

Augustynowicz, Monika ^{[1
]}

Bargenda-Lange, Agnieszka ^{[1
]}

Kalwak, Krzysztof ^{[2
]}

Zwolinska, Danuta ^{[1
]}

Musial, Kinga ^{[1
]}

机构：

[1] Wroclaw Med Univ, Dept Pediat Nephrol, Wroclaw, Poland

[2] Wroclaw Med Univ, Dept Bone Marrow Transplantat Oncol & Pediat Hema, Wroclaw, Poland

来源：

ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE | 2019年 / 28卷 / 08期

关键词：

chronic kidney disease; nephrotoxicity; acute tubular damage; renal outcome; hematopoietic stem cell transplantation; ACID-BINDING PROTEIN; GELATINASE-ASSOCIATED LIPOCALIN; SERUM CYSTATIN C; PREDICTIVE BIOMARKER; CYSTEINE PROTEINASES; RENAL DYSFUNCTION; TISSUE INHIBITOR; DIAGNOSIS; MOLECULE-1; KIM-1;

D O I：

10.17219/acem/101573

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Acute kidney injury (AKI), one of the major complications in children undergoing hematopoietic stem cell transplantation (HSCT), is an independent predictor of the patient's survival and a prognostic factor of progression to chronic kidney disease (CKD). Despite the multifaceted role of AKI, its early diagnosis in the course of HSCT remains a challenge. These difficulties may result from the inefficiency of traditional methods used to assess kidney function, like serum creatinine or estimated glomerular filtration rate. Moreover, the list of potential AKI markers tested in HSCT conditions is limited and does not involve indexes evaluated in the pediatric population. This review summarizes current knowledge on the pathophysiology of AKI developing in the course of HSCT; presents well-known markers of AKI that are potentially applicable in children who have undergone HSCT; discusses the role of new markers in diagnosing AKI and predicting the renal outcome in children undergoing HSCT; and analyzes the prospects for the use of new tools for assessing kidney injury in everyday clinical practice.

引用

页码：1111 / 1118

页数：8

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