TOWARD EARLIER DETECTION OF CHOROIDAL NEOVASCULARIZATION SECONDARY TO AGE-RELATED MACULAR DEGENERATION Multicenter Evaluation of a Preferential Hyperacuity Perimeter Designed as a Home Device

被引：29

作者：

Loewenstein, Anat

Ferencz, Joseph R. ^{[1
]}

Lang, Yaron ^{[2
]}

Yeshurun, Itamar ^{[3
]}

Pollack, Ayala ^{[4
]}

Siegal, Ruth ^{[5
]}

Lifshitz, Tova ^{[6
]}

Karp, Joseph ^{[7
]}

Roth, Daniel ^{[8
]}

Bronner, Guri ^{[9
]}

Brown, Justin ^{[10
]}

Mansour, Sam ^{[11
]}

Friedman, Scott ^{[12
]}

Michels, Mark ^{[13
]}

Johnston, Richards ^{[14
]}

Rapp, Moshe ^{[15
]}

Havilio, Moshe ^{[15
]}

Rafaeli, Omer ^{[15
]}

Manor, Yair ^{[15
]}

机构：

[1] Meir Med Ctr, Kefar Sava, Israel

[2] HaEmek Med Ctr, Afula, Israel

[3] Wolfson Med Ctr, Holon, Israel

[4] Kaplan Med Ctr, Rehovot, Israel

[5] Rabin Med Ctr, Petah Tiqwa, Israel

[6] Soroka Med Ctr, Beer Sheva, Israel

[7] Machon Mor, Ramat Gan, Israel

[8] Retina Vitreous Ctr, Toms River, NJ USA

[9] Retinal & Ophthalm Consultants, Foxman Foxman & Margolis, Northfield, NJ USA

[10] Charlotte Eye Ear Nose & Throat Associates, Charlotte, NC USA

[11] Virginia Retina Ctr, Leesburg, VA USA

[12] Cent Florida Retina Inst, Lakeland, FL USA

[13] Retina Care Specialists, Palm Beach Gardens, FL USA

[14] Edina Retina Consultants, Edina, MN USA

[15] Notal Vis Ltd, Tel Aviv, Israel

来源：

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES | 2010年 / 30卷 / 07期

关键词：

age-related macular degeneration; cho-roidal neovascularization; early detection; home device monitoring; preferential hyperacuity perimetry; SUBGROUP ANALYSIS; RANIBIZUMAB; VERTEPORFIN; MEMBRANES; THERAPY; PHP;

D O I：

10.1097/IAE.0b013e3181d1a75e

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: The primary purpose of this study was to evaluate the ability of a home device preferential hyperacuity perimeter to discriminate between patients with choroidal neovascularization (CNV) and intermediate age-related macular degeneration (AMD), and the secondary purpose was to investigate the dependence of sensitivity on lesion characteristics. Methods: All participants were tested with the home device in an unsupervised mode. The first part of this work was retrospective using tests performed by patients with intermediate AMD and newly diagnosed CNV. In the second part, the classifier was prospectively challenged with tests performed by patients with intermediate AMD and newly diagnosed CNV. The dependence of sensitivity on lesion characteristics was estimated with tests performed by patients with CNV of both parts. Results: In 66 eyes with CNV and 65 eyes with intermediate AMD, both sensitivity and specificity were 0.85. In the retrospective part (34 CNV and 43 intermediate AMD), sensitivity and specificity were 0.85 +/- 0.12 (95% confidence interval) and 0.84 +/- 0.11 (95% confidence interval), respectively. In the prospective part (32 CNV and 22 intermediate AMD), sensitivity and specificity were 0.84 +/- 0.13 (95% confidence interval) and 0.86 +/- 0.14 (95% confidence interval), respectively. Chi-square analysis showed no dependence of sensitivity on type (P = 0.44), location (P = 0.243), or size (P = 0.73) of the CNV lesions. Conclusion: A home device preferential hyperacuity perimeter has good sensitivity and specificity in discriminating between patients with newly diagnosed CNV and intermediate AMD. Sensitivity is not dependent on lesion characteristics. RETINA 30:1058-1064, 2010

引用

页码：1058 / 1064

页数：7

共 26 条

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