Mitoquinone mesylate attenuates brain inflammation in humanized mouse model of chronic HIV infection

被引：1

作者：

Satta, Sandro ^{[1
]}

Hugo, Cristelle ^{[1
]}

Sharma, Madhav ^{[1
]}

Rezek, Valerie ^{[2
]}

Kossyvakis, Athanassios ^{[1
]}

Sen Roy, Shubhendu ^{[1
]}

Kitchen, Scott ^{[2
]}

Kelesidis, Theodoros ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Div Infect Dis, Dept Med, Le Conte Ave,CHS 37-121, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Div Hematol & Oncol, Dept Med, Los Angeles, CA 90095 USA

来源：

AIDS | 2022年 / 36卷 / 11期

关键词：

MITOCHONDRIA-TARGETED ANTIOXIDANT; MITOQ; PATHOGENESIS;

D O I：

10.1097/QAD.0000000000003291

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

引用

页码：1609 / 1611

页数：3

共 10 条

[1] Mitochondrial Dysfunction in Neurodegenerative Diseases [J].

Johri, Ashu ;

Beal, M. Flint .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2012, 342 (03) :619-630

[2] Mitochondria-targeted antioxidant MitoQ ameliorates experimental mouse colitis by suppressing NLRP3 inflammasome-mediated inflammatory cytokines [J].

Dashdorj, Amarjargal ;

Jyothi, K. R. ;

Lim, Sangbin ;

Jo, Ara ;

Nguyen, Minh Nam ;

Ha, Joohun ;

Yoon, Kyung-Sik ;

Kim, Hyo Jong ;

Park, Jae-Hoon ;

Murphy, Michael P. ;

Kim, Sung Soo .

BMC MEDICINE, 2013, 11

[3] ApoA-I mimetics reduce systemic and gut inflammation in chronic treated HIV [J].

Daskou, Maria ;

Mu, William ;

Sharma, Madhav ;

Vasilopoulos, Hariclea ;

Heymans, Rachel ;

Ritou, Eleni ;

Rezek, Valerie ;

Hamid, Philip ;

Kossyvakis, Athanasios ;

Sen Roy, Shubhendu ;

Grijalva, Victor ;

Chattopadhyay, Arnab ;

Kitchen, Scott G. ;

Fogelman, Alan M. ;

Reddy, Srinivasa T. ;

Kelesidis, Theodoros .

PLOS PATHOGENS, 2022, 18 (01)

[4] The mitochondria-targeted antioxidant MitoQ modulates oxidative stress, inflammation and leukocyte-endothelium interactions in leukocytes isolated from type 2 diabetic patients [J].

Escribano-Lopez, Irene ;

Diaz-Morales, Noelia ;

Rovira-Llopis, Susana ;

de Maranon, Arantxa Martinez ;

Orden, Samuel ;

Alvarez, Angeles ;

Banuls, Celia ;

Rocha, Milagros ;

Murphy, Michael P. ;

Hernandez-Mijares, Antonio ;

Victor, Victor M. .

REDOX BIOLOGY, 2016, 10 :200-205

[5] Oxidative Stress during HIV Infection: Mechanisms and Consequences [J].

Ivanov, Alexander V. ;

Valuev-Elliston, Vladimir T. ;

Ivanova, Olga N. ;

Kochetkov, Sergey N. ;

Starodubova, Elizaveta S. ;

Bartosch, Birke ;

Isaguliants, Maria G. .

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2016, 2016

[6] MitoQ a mitochondria-targeted antioxidant, delays disease progression and alleviates pathogenesis in an experimental autoimmune encephalomyelitis mouse model of multiple sclerosis [J].

Mao, Peizhong ;

Manczak, Maria ;

Shirendeb, Ulziibat P. ;

Reddy, P. Hemachandra .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2013, 1832 (12) :2322-2331

[7] The Mitochondria-Targeted Antioxidant MitoQ Prevents Loss of Spatial Memory Retention and Early Neuropathology in a Transgenic Mouse Model of Alzheimer's Disease [J].

McManus, Meagan J. ;

Murphy, Michael P. ;

Franklin, James L. .

JOURNAL OF NEUROSCIENCE, 2011, 31 (44) :15703-15715

[8]

Saylor D, 2016, NAT REV NEUROL, V12, P234, DOI [10.1038/nrneurol.2016.27, 10.1038/nrneurol.2016.53]

[9] Animal and human studies with the mitochondria-targeted antioxidant MitoQ [J].

Smith, Robin A. J. ;

Murphy, Michael P. .

MITOCHONDRIAL RESEARCH IN TRANSLATIONAL MEDICINE, 2010, 1201 :96-103

[10] A novel role of NLRP3-generated IL-1β in the acute-chronic transition of peripheral lipopolysaccharide-elicited neuroinflammation: implications for sepsis-associated neurodegeneration [J].

Zhao, Zhan ;

Wang, Yubao ;

Zhou, Ran ;

Li, Yi ;

Gao, Yun ;

Tu, Dezhen ;

Wilson, Belinda ;

Song, Sheng ;

Feng, Jing ;

Hong, Jau-Shyong ;

Yakel, Jerrel L. .

JOURNAL OF NEUROINFLAMMATION, 2020, 17 (01)

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