One-year persistence of neutralizing anti-SARS-CoV-2 antibodies in dialysis patients recovered from COVID-19

被引:8
作者
Alfano, Gaetano [1 ,2 ,3 ]
Fontana, Francesco [2 ]
Morisi, Niccolo [1 ]
Giaroni, Francesco [1 ]
Mori, Giacomo [2 ]
Guaraldi, Giovanni [4 ]
Magistroni, Riccardo [1 ,2 ]
Cappelli, Gianni [1 ,2 ]
机构
[1] Univ Modena & Reggio Emilia, Surg Med & Dent Dept Morphol Sci, Sect Nephrol, Via Pozzo 71, I-41124 Modena, Italy
[2] Univ Hosp Modena, Nephrol Dialysis & Transplant Unit, Modena, Italy
[3] Univ Modena & Reggio Emilia, Clin & Expt Med PhD Program, Modena, Italy
[4] Univ Hosp Modena, Clin Infect Dis, Modena, Italy
关键词
antibody; COVID-19; dialysis; immunity; Sars-CoV-2; vaccine;
D O I
10.1111/hdi.12963
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
The immunological mechanisms that modulate immune response to SARS-CoV-2 infection remain elusive. Little is known on the magnitude and the durability of antibody response against COVID-19. There is consensus that patients with immune dysfunction, such as dialysis patients, may be unable to mount a robust and durable humoral immunity after infections. Recent studies showed that dialysis patients seroconverted after COVID-19, but data on the durability of the immune response are missing. We reported the data of a durable anti-spike protein seroconversion after natural SARS-CoV-2 infection in three patients on hemodialysis with a mean age of 67.2 +/- 13.8 years. A mean antibody titer of 212.6 +/- 174.9 UA/ml (Liaison (R), DiaSorin) was found after one year (range, 366-374 days) from the diagnosis of COVID-19. In conclusion, this case series provided evidence that patients receiving hemodialysis who recovered from severe COVID-19 were able to mount a long-lasting immune response against SARS-CoV-2. Although the protective capacity of this long-term immunity remains to be determined, these patients did not report signs of reinfection after recovery from COVID-19.
引用
收藏
页码:E53 / E56
页数:4
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