Mucoadhesive drug delivery systems

被引：224

作者：

Carvalho, Flavia Chiva ^{[1
]}

Bruschi, Marcos Luciano ^{[2
]}

Evangelista, Raul Cesar ^{[1
,3
]}

Daflon Gremiao, Maria Palmira ^{[1
,3
]}

机构：

[1] UNESP, Sch Pharmaceut Sci, Pharmaceut Sci Postgrad Program, Sao Paulo State Univ, BR-14801902 Araraquara, SP, Brazil

[2] Univ Estadual Maringa, State Univ Maringa, Dept Pharm, Maringa, Parana, Brazil

[3] UNESP, Sao Paulo State Univ, Dept Drugs & Pharmaceut, Sch Pharmaceut Sci, BR-14801902 Araraquara, SP, Brazil

来源：

BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2010年 / 46卷 / 01期

关键词：

Mucoadhesion; Bioadhesion; Mucoadhesive systems; Drugs/delivery; MODIFIED POLY(ACRYLIC ACID); IN-VITRO; RHEOLOGICAL CHARACTERIZATION; PERIODONTAL-DISEASE; MICROPARTICLES; BIOADHESION; HYDROGELS; POLYMERS; CHITOSAN; MECHANISMS;

D O I：

10.1590/S1984-82502010000100002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Drug actions can be improved by developing new drug delivery systems, such as the mucoadhesive system. These systems remain in close contact with the absorption tissue, the mucous membrane, releasing, the drug at the action site leading to a bioavailability increase and both local and systemic effects. Mucoadhesion is currently explained by six theories: electronic, adsorption, wettability, diffusion. fracture and mechanical. Several in vitro and in vivo methodologies arc proposed for studying its mechanisms. However, mucoadhesion is not yet well understood. The aim of this study was to review the mechanisms and theories involved in mucoadhesion, as well as to describe the most-used methodologies and polymers in mucoadhesive drug delivery systems.

引用

页码：1 / 17

页数：17

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