Comparative effect of C3a and C5a on adhesion molecule expression on neutrophils and endothelial cells

被引:85
作者
Foreman, KE
Glovsky, MM
Warner, RL
Horvath, SJ
Ward, PA
机构
[1] HUNTINGTON MEM HOSP,CTR ASTHMA & ALLERGY,PASADENA,CA
[2] CALTECH,BECKMAN INST,PASADENA,CA 91125
[3] WARNER LAMBERT PARKE DAVIS,DIV RES,ANN ARBOR,MI
关键词
D O I
10.1007/BF01487740
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Complement activation is known to enhance neutrophil binding to human umbilical vein endothelial cells (HUVECs). Recently, we have shown that recombinant human C5a upregulates P-selectin in HUVECs. Unstimulated human neutrophil binding is also increased on C5a stimulated HUVECs. We demonstrate in this report that C5a upregulates CD11b/CD18 in human neutrophils. Also shown is that synthetic C3a(57-77) and an analog 15 amino acid C3a peptide (C3a(15)) neither upregulate CD11b/CD18 nor do the C3a peptides increase P-selectin, ICAM-1 or E-selectin in HUVECs. Thus C5a and not C3a is responsible for early (similar to 30 minutes) neutrophil adhesion to endothelial cells after complement activation.
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页码:1 / 9
页数:9
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