Effect of prenylated flavonoids and chalcones isolated from Artocarpus species on platelet aggregation in human whole blood

被引：29

作者：

Jantan, Ibrahim ^{[1
]}

Yasin, Yusyila H. Mohd ^{[1
]}

Jamil, Shajarahtunnur ^{[2
]}

Sirat, Hasnah ^{[2
]}

Basar, Norazah ^{[2
]}

机构：

[1] Univ Kebangsaan Malaysia, Fac Pharm, Kuala Lumpur 50300, Malaysia

[2] Univ Teknol Malaysia, Fac Sci, Dept Chem, Skudai, Johore, Malaysia

来源：

JOURNAL OF NATURAL MEDICINES | 2010年 / 64卷 / 03期

关键词：

Artocarpus species; Antiplatelet aggregation; Human whole blood; Cycloheterophyllin; 2; 4; '-dihydroxy-4-methoxy-3; '-prenyldihydrochalcone; Arachidonic acid; ANTIPLATELET ACTIVITY; CONSTITUENTS; PRENYLFLAVONOIDS; AGGREGOMETER; INHIBITION; PLANTS;

D O I：

10.1007/s11418-010-0410-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five prenylflavonoids and two prenylchalcones from Artocarpus lowii King, A. scortechinii King and A. teysmanii Miq., and acetylated derivatives of cycloheterophyllin and artonin E were investigated for their ability to inhibit arachidonic acid (AA), collagen and adenosine diphosphate (ADP)-induced platelet aggregation in human whole blood by using an electrical impedance method. Among the tested compounds, only cycloheterophyllin inhibited AA-induced platelet aggregation with an IC(50) value of 100.9 mu M. It also showed strong inhibition against ADP-induced aggregation, with an IC(50) value of 57.1 mu M. Isobavachalcone, 2',4'-dihydroxy-4-methoxy-3'-prenyldihydrochalcone, cycloartobiloxanthone, artonin E and artonin E triacetate showed selective inhibition against ADP-induced aggregation, with IC(50) values ranging from 55.3 to 192.0 mu M, but did not show such effect against other inducers.

引用

页码：365 / 369

页数：5

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