May ratio of neutrophil to lymphocyte be useful in predicting the risk of developing preeclampsia? A pilot study

被引:62
作者
Kurtoglu, Emel [1 ]
Kokcu, Arif [1 ]
Celik, Handan [1 ]
Tosun, Migraci [1 ]
Malatyalioglu, Erdal [1 ]
机构
[1] Ondokuz Mayis Univ, Dept Obstet & Gynecol, Sch Med, TR-55139 Kurupelit, Samsun, Turkey
关键词
Lymphocyte; neutrophil; preeclampsia; pregnancy; EPITHELIAL OVARIAN-CANCER; WOMEN; LEUKOCYTES; RECEPTOR;
D O I
10.3109/14767058.2014.905910
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: The aim of the study was to evaluate the relationship between neutrophil to lymphocyte ratio (NLR) and preeclampsia. Methods: Demographic data and laboratory tests for NLR of 203 pregnant women (73 normotensive pregnants, 23 pregnants with mild preeclampsia and 107 pregnants with severe preeclampsia) were retrospectively analyzed. Neutrophil to lymphocyte ratios were compared between the study groups. Results: Preeclamptic pregnant women had smaller gestation weeks, lower hemoglobin level and fetal birth weight than that of normal pregnant women. NLR in preeclamptic group was significantly higher than that of normal group (p = 0.023) and area under ROC curve was found statistically significant (p = 0.023). However, there was no statistically significant relationship between NLR and severity, proteinuria level, subjective symptoms and onset time of the disease. Conclusion: The findings showed that the measurement of NLR periodically may be useful to predict high-risk pregnancies in terms of preeclampsia, but further studies are needed to determine its contribution.
引用
收藏
页码:97 / 99
页数:3
相关论文
共 22 条
[1]   Elevated placental soluble vascular endothelial growth factor receptor-1 inhibits angiogenesis in preeclampsia [J].
Ahmad, S ;
Ahmed, A .
CIRCULATION RESEARCH, 2004, 95 (09) :884-891
[2]   Expression of inflammatory cytokines in placentas from women with preeclampsia [J].
Benyo, DF ;
Smarason, A ;
Redman, CWG ;
Sims, C ;
Conrad, KP .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (06) :2505-2512
[3]  
BOHN H, 1983, ONCODEV BIOL MED, V4, P343
[4]   Increased Neutrophil Numbers Account for Leukocytosis in Women with Preeclampsia [J].
Canzoneri, Bernard J. ;
Lewis, David F. ;
Groome, Lynn ;
Wang, Yuping .
AMERICAN JOURNAL OF PERINATOLOGY, 2009, 26 (10) :729-732
[5]   Adverse perinatal outcomes and risk factors for Preeclampsia in women with chronic hypertension - A prospective study [J].
Chappell, Lucy C. ;
Enye, Stephen ;
Seed, Paul ;
Briley, Annette L. ;
Poston, Lucilla ;
Shennan, Andrew H. .
HYPERTENSION, 2008, 51 (04) :1002-1009
[6]  
CHEIFETZ S, 1992, J BIOL CHEM, V267, P19027
[7]  
Cho CH, 1997, DEV GENET, V20, P320, DOI 10.1002/(SICI)1520-6408(1997)20:4<320::AID-DVG3>3.0.CO
[8]  
2-9
[9]   Pre-treatment neutrophil to lymphocyte ratio is elevated in epithelial ovarian cancer and predicts survival after treatment [J].
Cho, HanByoul ;
Hur, Hye Won ;
Kim, Sang Wun ;
Kim, Sung Hoon ;
Kim, Jae Hoon ;
Kim, Young Tae ;
Lee, Kook .
CANCER IMMUNOLOGY IMMUNOTHERAPY, 2009, 58 (01) :15-23
[10]  
Daniel AK, 2007, CURRENT DIAGNOSIS TR, P156