Codon Usage in Trypanosomatids: The Bias of Expression

被引：1

作者：

Erben, Esteban D. ^{[1
]}

Clayton, Christine ^{[2
]}

机构：

[1] DKFZ ZMBH Alliance, German Canc Res Ctr DKFZ, Neuenheimer Feld 280, D-69120 Heidelberg, Germany

[2] Heidelberg Univ, Zentrum Mol Biol, DKFZ ZMBH Alliance, Neuenheimer Feld 282, D-69120 Heidelberg, Germany

来源：

TRENDS IN PARASITOLOGY | 2018年 / 34卷 / 08期

关键词：

MESSENGER-RNA DECAY; OPTIMALITY;

D O I：

10.1016/j.pt.2018.06.001

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Translation and RNA decay, two processes in which all mRNAs are engaged, are intimately related processes. Two new studies demonstrate that, in trypanosomatids, codon usage largely shapes mRNA abundance in a translation-dependent manner. The findings indicate that mRNA decay control by codon choice is an ancient and conserved mechanism.

引用

收藏

页码：635 / 637

页数：4

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