Effect of repeated oral infection of hamsters with scrapie

被引：56

作者：

Diringer, H

Roehmel, J

Beekes, M

机构：

[1] Bundesinst Infekt Krankheiten & Nicht Ubertragbar, Robert Koch Inst, Fachgebiet 123, D-13353 Berlin, Germany

[2] Bundesinst Arzneimittel & Med Prod, D-13347 Berlin, Germany

来源：

JOURNAL OF GENERAL VIROLOGY | 1998年 / 79卷

关键词：

D O I：

10.1099/0022-1317-79-3-609

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The development of a transmissible spongiform encephalopathy upon uptake of the infectious agent in feed was studied in the model system scrapie in hamsters. Compared to single dosing, repeated dosing caused disease at a considerable higher incidence. The risk of infection was higher when the time interval between repetitive dosing was short. There was a statistically significant trend of clearance of infectivity with time.

引用

页码：609 / 612

页数：4

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