Inspecting chiral molecules by Raman optical activity spectroscopy

被引:69
作者
Parchansky, Vaclav [1 ,2 ]
Kapitan, Josef [3 ]
Bour, Petr [1 ,2 ]
机构
[1] Acad Sci Czech Republ, Inst Organ Chem & Biochem, Prague 16610, Czech Republic
[2] Inst Chem Technol, Dept Analyt Chem, CR-16628 Prague, Czech Republic
[3] Palacky Univ, Dept Opt, Olomouc 77146, Czech Republic
关键词
VIBRATIONAL CIRCULAR-DICHROISM; FUNCTIONAL THEORY CALCULATIONS; AB-INITIO INTERPRETATION; ABSOLUTE-CONFIGURATION; ACTIVITY SPECTRA; PROPERTY TENSORS; HIGH-THROUGHPUT; BETA-SHEET; PROTEIN; TRANSITION;
D O I
10.1039/c4ra10416a
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Raman optical activity (ROA) is a relatively new method combining the variability of scattering experiments with the structural sensitivity of chiral spectroscopy. Typically, ROA can be employed to determine absolute configuration (AC) of organic compounds, chiral metal complexes, and conformation of biologically relevant chiral molecules in solution. The present review covers the latest theoretical and experimental studies documenting the possibilities and limitations of the technique to probe molecular structure. The quantum-chemical apparatus necessary for spectral interpretation is introduced, and example applications provided, including recent data on possible extensions of the ROA spectroscopy to a more diverse systems.
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页码:57125 / 57136
页数:12
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