Opportunities in precision psychiatry using PET neuroimaging in psychosis

被引:5
作者
Coughlin, Jennifer M. [1 ,2 ]
Horti, Andrew G. [2 ]
Pomper, Martin G. [1 ,2 ]
机构
[1] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA
[2] Johns Hopkins Univ, Sch Med, Russell H Morgan Dept Radiol & Radiol Sci, Baltimore, MD USA
关键词
Precision medicine; Psychosis; PET imaging; Dopamine; alpha7 nicotinic acetylcholine receptor; Neuroimmunity; NICOTINIC ACETYLCHOLINE-RECEPTORS; DOPAMINE SYNTHESIS CAPACITY; SCHIZOPHRENIA METAANALYSIS; NEGATIVE SYMPTOMS; BRAIN MICROGLIA; SUBUNIT; NEUROINFLAMMATION; RADIOTRACER; DYSFUNCTION; HYPOTHESIS;
D O I
10.1016/j.nbd.2019.03.016
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
With the movement toward precision medicine in healthcare, recent studies of individuals with psychosis have begun to explore positron emission tomography (PET) as a tool to test for biochemical signatures that may distinguish subtypes of psychosis that guide subtype-specific therapeutic interventions. This review presents selected PET findings that exemplify early promise in using molecular imaging to predict treatment response, provide rationale for new therapeutic targets, and monitor target engagement in biomarker-defined subtypes of psychosis. PET data, among other data types, may prove useful in the scientific pursuit of identifying precision strategies to improve clinical outcomes for individuals with psychosis.
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收藏
页数:6
相关论文
共 78 条
  • [1] Neuroinflammatory response to lipopolysaccharide is exacerbated in mice genetically deficient in cyclooxygenase-2
    Aid, Saba
    Langenbach, Robert
    Bosetti, Francesca
    [J]. JOURNAL OF NEUROINFLAMMATION, 2008, 5 (1)
  • [2] EXPRESSION OF THE RECEPTOR FOR MACROPHAGE-COLONY-STIMULATING FACTOR BY BRAIN MICROGLIA AND ITS UP-REGULATION IN BRAINS OF PATIENTS WITH ALZHEIMERS-DISEASE AND AMYOTROPHIC-LATERAL-SCLEROSIS
    AKIYAMA, H
    NISHIMURA, T
    KONDO, H
    IKEDA, K
    HAYASHI, Y
    MCGEER, PL
    [J]. BRAIN RESEARCH, 1994, 639 (01) : 171 - 174
  • [3] [Anonymous], 2007, Journal of Nuclear Medicine
  • [4] [Anonymous], ALPHA7 NICOTINIC REC
  • [5] [Anonymous], 12 INT S FUNCT NEUR
  • [6] [Anonymous], DOPA PET STUDY
  • [7] [Anonymous], SCHIZOPHR B
  • [8] Investigating the neuroimmunogenic architecture of schizophrenia
    Birnbaum, R.
    Jaffe, A. E.
    Chen, Q.
    Shin, J. H.
    Kleinman, J. E.
    Hyde, T. M.
    Weinberger, D. R.
    [J]. MOLECULAR PSYCHIATRY, 2018, 23 (05) : 1251 - 1260
  • [9] Effectiveness of second-generation antipsychotics in patients with treatment-resistant schizophrenia: A review and meta-analysis of randomized trials
    Chakos, M
    Lieberman, J
    Hoffman, E
    Bradford, D
    Sheitman, B
    [J]. AMERICAN JOURNAL OF PSYCHIATRY, 2001, 158 (04) : 518 - 526
  • [10] Toward Precision Healthcare: Context and Mathematical Challenges
    Colijn, Caroline
    Jones, Nick
    Johnston, Iain G.
    Yaliraki, Sophia
    Barahona, Mauricio
    [J]. FRONTIERS IN PHYSIOLOGY, 2017, 8