Recent Advances in Nanoparticle-Mediated Delivery of Anti-Inflammatory Phytocompounds

被引：71

作者：

Conte, Raffaele ^{[1
]}

Marturano, Valentina ^{[2
,3
]}

Peluso, Gianfranco ^{[1
]}

Calarco, Anna ^{[1
]}

Cerruti, Pierfrancesco ^{[2
]}

机构：

[1] IBAF CNR, Inst Agroenvironm & Forest Biol, Via Pietro Castellino 111, I-80131 Naples, Italy

[2] CNR, IPCB, Via Campi Flegrei 34, I-80078 Pozzuoli, NA, Italy

[3] Univ Naples Federico II, Dept Chem Sci, Via Cynthia 4, I-80125 Naples, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2017年 / 18卷 / 04期

关键词：

inflammation; phytochemicals; nanosized delivery systems; polyphenols; carbohydrates; cannabinoids; terpenoids; essential oils; nanoparticles; nanocapsules; SOLID LIPID NANOPARTICLES; COMARUM-PALUSTRE L; DRUG-DELIVERY; ESSENTIAL OILS; BETA-CYCLODEXTRIN; IN-VITRO; P-CYMENE; NEURODEGENERATIVE DISEASES; AUTOINFLAMMATORY DISEASES; ANTIBACTERIAL PROPERTIES;

D O I：

10.3390/ijms18040709

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phytocompounds have been used in medicine for decades owing to their potential in anti-inflammatory applications. However, major difficulties in achieving sustained delivery of phyto-based drugs are related to their low solubility and cell penetration, and high instability. To overcome these disadvantages, nanosized delivery technologies are currently in use for sustained and enhanced delivery of phyto-derived bioactive compounds in the pharmaceutical sector. This review focuses on the recent advances in nanocarrier-mediated drug delivery of bioactive molecules of plant origin in the field of anti-inflammatory research. In particular, special attention is paid to the relationship between structure and properties of the nanocarrier and phytodrug release behavior.

引用

页数：23

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