A Promoter Polymorphism of the Vitamin D Metabolism Gene Cyp24a1 is Associated with Severe Atopic Dermatitis in Adults

被引：22

作者：

Hallau, Jana ^{[1
]}

Hamann, Lutz ^{[2
]}

Schumann, Ralf R. ^{[2
]}

Worm, Margitta ^{[1
]}

Heine, Guido ^{[1
]}

机构：

[1] Charite Univ Med Berlin, CCM, Allergie Ctr Charite, Klin Dermatol Venerol & Allergol, Charitepl 1, DE-10117 Berlin, Germany

[2] Charite Univ Med Berlin, Inst Mikrobiol & Hyg, DE-10117 Berlin, Germany

来源：

ACTA DERMATO-VENEREOLOGICA | 2016年 / 96卷 / 02期

关键词：

vitamin D; atopic dermatitis; metabolism; cyp24a1; cyp27b1; SERUM 25-HYDROXYVITAMIN D; D-RECEPTOR GENE; MULTIPLE-SCLEROSIS; ASTHMA;

D O I：

10.2340/00015555-2226

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Atopic dermatitis (AD) is a chronic inflammatory skin disease in which genetic and environmental factors result in impaired epidermal barrier functioning and an altered immune response. Vitamin D influences these 2 pathomechanisms, and beneficial results have been suggested in AD. The aim of this study was to investigate the potential roles of the 2 essential vitamin D metabolizing enzymes. The frequencies of 6 common polymorphisms in the genes encoding the vitamin D synthesizing enzyme Cyp27b1 or the inactivating enzyme Cyp24a1 were assessed in 281 patients with AD and 278 healthy donors in a case-control setting. The Cyp24a1 rs2248359-major C allele was significantly over-represented in patients with AD compared with controls, which was more pronounced in patients with severe AD. In addition, haplotypes of the Cyp24a1 and Cyp27b1 genes were associated with AD. These data support that vitamin D mediates beneficial functions in AD and suggest that future studies on the impact of vitamin D on AD should consider the individual genotypes of the vitamin D metabolizing enzymes.

引用

页码：169 / 172

页数：4

共 15 条

[1] Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20 [J].

Bahlo, Melanie ;

Booth, David R. ;

Broadley, Simon A. ;

Brown, Matthew A. ;

Foote, Simon J. ;

Griffiths, Lyn R. ;

Kilpatrick, Trevor J. ;

Lechner-Scott, Jeanette ;

Moscato, Pablo ;

Perreau, Victoria M. ;

Rubio, Justin P. ;

Scott, Rodney J. ;

Stankovich, Jim ;

Stewart, Graeme J. ;

Taylor, Bruce V. ;

Wiley, James ;

Clarke, Glynnis ;

Cox, Mathew B. ;

Csurhes, Peter A. ;

Danoy, Patrick ;

Drysdale, Karen ;

Field, Judith ;

Foote, Simon J. ;

Greer, Judith M. ;

Guru, Preethi ;

Hadler, Johanna ;

McMorran, Brendan J. ;

Jensen, Cathy J. ;

Johnson, Laura J. ;

McCallum, Ruth ;

Merriman, Marilyn ;

Merriman, Tony ;

Pryce, Karen ;

Tajouri, Lotfi ;

Wilkins, Ella J. ;

Browning, Brian L. ;

Browning, Sharon R. ;

Perera, Devindri ;

Butzkueven, Helmut ;

Carroll, William M. ;

Chapman, Caron ;

Kermode, Allan G. ;

Marriott, Mark ;

Mason, Deborah ;

Heard, Robert N. ;

Pender, Michael P. ;

Slee, Mark ;

Tubridy, Niall ;

Willoughby, Ernest .

NATURE GENETICS, 2009, 41 (07) :824-U84

[2] Asthma and genes encoding components of the vitamin D pathway [J].

Bosse, Yohan ;

Lemire, Mathieu ;

Poon, Audrey H. ;

Daley, Denise ;

He, Jian-Qing ;

Sandford, Andrew ;

White, John H. ;

James, Alan L. ;

Musk, Arthur William ;

Palmer, Lyle J. ;

Raby, Benjamin A. ;

Weiss, Scott T. ;

Kozyrskyj, Anita L. ;

Becker, Allan ;

Hudson, Thomas J. ;

Laprise, Catherine .

RESPIRATORY RESEARCH, 2009, 10

[3] Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study [J].

Brehm, John M. ;

Schuemann, Brooke ;

Fuhlbrigge, Anne L. ;

Hollis, Bruce W. ;

Strunk, Robert C. ;

Zeiger, Robert S. ;

Weiss, Scott T. ;

Litonjua, Augusto A. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2010, 126 (01) :52-58

[4]

Camargo Jr CA, 2014, J ALLERGY CLIN IMMUN, V134

[5] Contribution of a Common Variant in the Promoter of the 1-α-Hydroxylase Gene (CYP27B1) to Fracture Risk in the Elderly [J].

Clifton-Bligh, Roderick J. ;

Nguyen, Tuan V. ;

Au, Amy ;

Bullock, Martyn ;

Cameron, Ian ;

Cumming, Robert ;

Chen, Jian Sheng ;

March, Lyn M. ;

Seibel, Markus J. ;

Sambrook, Philip N. .

CALCIFIED TISSUE INTERNATIONAL, 2011, 88 (02) :109-116

[6] Targeting the vitamin D receptor inhibits the B cell-dependent allergic immune response [J].

Hartmann, B. ;

Heine, G. ;

Babina, M. ;

Steinmeyer, A. ;

Zuegel, U. ;

Radbruch, A. ;

Worm, M. .

ALLERGY, 2011, 66 (04) :540-548

[7] Association of vitamin D receptor gene polymorphisms with severe atopic dermatitis in adults [J].

Heine, G. ;

Hoefer, N. ;

Franke, A. ;

Noethling, U. ;

Schumann, R. R. ;

Hamann, L. ;

Worm, M. .

BRITISH JOURNAL OF DERMATOLOGY, 2013, 168 (04) :855-858

[8] Vitamin D deficiency in patients with cutaneous lupus erythematosus is prevalent throughout the year [J].

Heine, G. ;

Lahl, A. ;

Mueller, C. ;

Worm, M. .

BRITISH JOURNAL OF DERMATOLOGY, 2010, 163 (04) :863-865

[9] Serum 25-hydroxyvitamin D and IgE - a significant but nonlinear relationship [J].

Hyppoenen, E. ;

Berry, D. J. ;

Wjst, M. ;

Power, C. .

ALLERGY, 2009, 64 (04) :613-620

[10] Bioinformatics for the 'bench biologist': how to find regulatory regions in genomic DNA [J].

Nardone, J ;

Lee, DU ;

Ansel, KM ;

Rao, A .

NATURE IMMUNOLOGY, 2004, 5 (08) :768-774

← 1 2 →