Chemoenzymatic synthesis of tumor-associated antigen N3 minor octasaccharide

被引：2

作者：

Han, Zhipeng ^{[1
,2
]}

Chen, Congcong ^{[1
,2
]}

Meng, Caicai ^{[1
,2
]}

Gao, Tian ^{[1
,2
]}

Peng, Peng ^{[1
,2
]}

Chen, Xi ^{[3
]}

Wang, Fengshan ^{[1
,2
,4
]}

Cao, Hongzhi ^{[1
,2
,5
]}

机构：

[1] Shandong Univ, Nat Glycoengn Res Ctr, Shandong Prov Key Lab Carbohydrate Chem & Glycobi, Jinan, Shandong, Peoples R China

[2] Shandong Univ, Sch Pharmaceut Sci, Jinan, Shandong, Peoples R China

[3] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA

[4] Shandong Univ, Inst Biochem & Biotechnol Drugs, Minist Educ, Key Lab Chem Biol Nat Prod, Jinan, Shandong, Peoples R China

[5] Shandong Univ, State Key Lab Microbial Technol, Jinan, Shandong, Peoples R China

来源：

JOURNAL OF CARBOHYDRATE CHEMISTRY | 2016年 / 35卷 / 8-9期

基金：

中国国家自然科学基金;

关键词：

Chemoenzymatic synthesis; glycosyltransferase; human milk oligosaccharide; N3 minor antigen; HUMAN-MILK OLIGOSACCHARIDES; MULTIENZYME OPME SYNTHESIS; SIALYL; HMOS;

D O I：

10.1080/07328303.2017.1315123

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A highly efficient chemoenzymatic approach was developed for the preparative scale synthesis of complex tumor-associated antigen N3 minor octasaccharide. The success of this approach relies on the highly efficient one-pot multi-enzyme based sequential enzymatic elongation of a chemically synthesized branched tetrasaccharide core structure.

引用

页码：412 / 422

页数：11

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