Molecular surveillance of antimalarial drug resistance related genes in Plasmodium falciparum isolates from Eritrea

被引：7

作者：

Menegon, Michela ^{[1
]}

Nurahmed, Abduselam M. ^{[2
]}

Talha, Albadawi A. ^{[2
]}

Nour, Bakri Y. M. ^{[3
]}

Severini, Carlo ^{[1
]}

机构：

[1] Ist Super Sanita, Dept Infect Parasit & Immunomediated Dis, Viale Regina Elena 299, I-00161 Rome, Italy

[2] Univ Gezira, Fac Med Lab Sci, POB 20, Wad Madani, Sudan

[3] Univ Gezira, Blue Nile Res Natl Inst Communicable Dis, POB 20, Wad Madani, Sudan

来源：

ACTA TROPICA | 2016年 / 157卷

关键词：

Plasmodium falciparum; Eritrea; Drug resistance; Kelch; 13; propeller; Pfmdr1; Pfcrt; ARTEMISININ RESISTANCE; IN-VITRO; MUTATIONS; MALARIA; PFMDR1; AMODIAQUINE; AFRICA; SPREAD;

D O I：

10.1016/j.actatropica.2016.02.007

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The introduction of artemisinin-based combination therapy has led to extraordinary results in malaria control, however the recent emergence of partial resistance to artemisinin therapy in Southeast Asia jeopardizes these successes. This study aimed at investigating resistance to the antimalarial drugs by evaluating the polymorphisms in the Pfk13, Pfcrt and Pfmdr1 genes in Plasmodium falciparum isolates obtained from patients in Eritrea. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：158 / 161

页数：4

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