Haematological effects of oral administration of bitopertin, a glycine transport inhibitor, in patients with non-transfusion-dependent β-thalassaemia

被引：15

作者：

Taher, Ali T. ^{[1
]}

Viprakasit, Vip ^{[2
,3
]}

Cappellini, Maria Domenica ^{[4
]}

Kraus, Dominik ^{[5
]}

Cech, Patrick ^{[5
]}

Volz, Dietmar ^{[5
]}

Winter, Erica ^{[6
]}

Nave, Stephane ^{[5
]}

Dukart, Juergen ^{[5
,7
,8
]}

Khwaja, Omar ^{[5
]}

Koerner, Annette ^{[5
]}

Hermosilla, Ricardo ^{[5
]}

Brugnara, Carlo ^{[9
,10
]}

机构：

[1] Amer Univ Beirut, Med Ctr, Dept Internal Med, Div Hematol & Oncol, Beirut, Lebanon

[2] Mahidol Univ, Dept Pediat, Bangkok, Thailand

[3] Mahidol Univ, Div Hematol & Oncol, Siriraj Thalassemia Ctr, Bangkok, Thailand

[4] Univ Milan, Dept Med, CaGranda Fdn IRCCS, Milan, Italy

[5] Roche Innovat Ctr Basel, Roche Pharma Res & Early Dev, Basel, Switzerland

[6] Roche Innovat Ctr, Roche Pharma Res & Early Dev, New York, NY USA

[7] Res Ctr Julich, Inst Neurosci & Med Brain & Behav INM 7, Julich, Germany

[8] Heinrich Heine Univ Dusseldorf, Med Fac, Inst Syst Neurosci, Dusseldorf, Germany

[9] Boston Childrens Hosp, Dept Lab Med, Boston, MA USA

[10] Harvard Med Sch, Dept Pathol, Boston, MA 02115 USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2021年 / 194卷 / 02期

关键词：

bitopertin; haem; iron; reactive oxygen species; beta-thalassemia; ERYTHROPOIESIS;

D O I：

10.1111/bjh.17479

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：474 / 477

页数：4

共 24 条

[21] Soluble form of transferrin receptor-1 level is associated with the age at first diagnosis and the risk of therapeutic intervention and iron overloading in patients with non-transfusion-dependent thalassemia
Paolo Ricchi
Antonella Meloni
Silvia Costantini
Anna Spasiano
Tiziana Di Matola
Alessia Pepe
Patrizia Cinque
Aldo Filosa
Annals of Hematology, 2017, 96 : 1541 - 1546
[22] Clinical utility of serum ferritin thresholds for guiding iron chelation therapy when magnetic resonance imaging is unavailable in patients with non-transfusion-dependent thalassaemias - response to Ang et al
Taher, Ali T.
BRITISH JOURNAL OF HAEMATOLOGY, 2017, 176 (06) : 989 - 990
[23] Efficacy and safety of LentiGlobin gene therapy in patients with transfusion-dependent β-thalassaemia and non-β0/β0 genotypes: Updated results from the completed phase 1/2 Northstar and ongoing phase 3 Northstar-2 studies
Porter, J. B.
Walters, M. C.
Kwiatkowski, J. L.
Hongeng, S.
Rasko, J. E. J.
Sauer, M. G.
Thrasher, A. J.
Thuret, I.
Schiller, G. J.
Elliot, H.
Deary, B.
Chen, Y.
Tao, G.
Asmal, M.
Locatelli, F.
Thompson, A. A.
BRITISH JOURNAL OF HAEMATOLOGY, 2019, 185 : 23 - 23
[24] Betibeglogene autotemcel gene therapy in patients with transfusion-dependent, severe genotype β-thalassaemia (HGB-212): a non-randomised, multicentre, single-arm, open-label, single-dose, phase 3 trial
Kwiatkowski, Janet L.
Walters, Mark C.
Hongeng, Suradej
Yannaki, Evangelia
Kulozik, Andreas E.
Kunz, Joachim B.
Sauer, Martin G.
Thrasher, Adrian J.
Thuret, Isabelle
Lal, Ashutosh
Tao, Ge
Ali, Shamshad
Thakar, Himal L.
Elliot, Heidi
Lodaya, Ankit
Lee, Ji
Colvin, Richard A.
Locatelli, Franco
Thompson, Alexis A.
LANCET, 2024, 404 (10468): : 2175 - 2186

← 1 2 3 →